Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease.

Angiotensin II / blood Angiotensinogen / genetics Animals Antihypertensive Agents / pharmacology Arterial Pressure / drug effects Captopril / pharmacology Disease Models, Animal Kidney / drug effects Liver / metabolism Losartan / pharmacology RNA, Small Interfering Rats Renal Insufficiency, Chronic / genetics Renin-Angiotensin System / drug effects
RNA, small interfering cardiac hypertrophy hypertension renal insufficiency, chronic renin-angiotensin system

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
05 05 2021
Historique:
pubmed: 16 3 2021
medline: 15 1 2022
entrez: 15 3 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.120.16876 PMID: 33719507
pubmed: 33719507
doi: 10.1161/HYPERTENSIONAHA.120.16876
doi:

Substances chimiques

Antihypertensive Agents 0
RNA, Small Interfering 0
Angiotensinogen 11002-13-4
Angiotensin II 11128-99-7
Captopril 9G64RSX1XD
Losartan JMS50MPO89

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1600-1612

Auteurs

Dominique M Bovée (DM)

Division of Vascular Medicine and Pharmacology (D.M.B., L.R., E.U., R.v.V., I.M.G., A.H.J.D.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Division of Nephrology and Transplantation, Department of Internal Medicine (D.M.B., E.U., E.J.H.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Liwei Ren (L)

Division of Vascular Medicine and Pharmacology (D.M.B., L.R., E.U., R.v.V., I.M.G., A.H.J.D.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People's Hospital) of Jinan University, China (L.R.).

Estrellita Uijl (E)

Division of Vascular Medicine and Pharmacology (D.M.B., L.R., E.U., R.v.V., I.M.G., A.H.J.D.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Division of Nephrology and Transplantation, Department of Internal Medicine (D.M.B., E.U., E.J.H.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Marian C Clahsen-van Groningen (MC)

Department of Pathology (M.C.C.-v.G.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Richard van Veghel (R)

Division of Vascular Medicine and Pharmacology (D.M.B., L.R., E.U., R.v.V., I.M.G., A.H.J.D.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Ingrid M Garrelds (IM)

Division of Vascular Medicine and Pharmacology (D.M.B., L.R., E.U., R.v.V., I.M.G., A.H.J.D.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Oliver Domenig (O)

Attoquant Diagnostics, Vienna, Austria (O.D., M.P.).

Marko Poglitsch (M)

Attoquant Diagnostics, Vienna, Austria (O.D., M.P.).

Ivan Zlatev (I)

Alnylam Pharmaceuticals, Cambridge, MA (I.Z., J.B.K., S.H., L.M., D.F.).

Jae B Kim (JB)

Alnylam Pharmaceuticals, Cambridge, MA (I.Z., J.B.K., S.H., L.M., D.F.).

Stephen Huang (S)

Alnylam Pharmaceuticals, Cambridge, MA (I.Z., J.B.K., S.H., L.M., D.F.).

Lauren Melton (L)

Alnylam Pharmaceuticals, Cambridge, MA (I.Z., J.B.K., S.H., L.M., D.F.).

Xifeng Lu (X)

Department of Physiology, AstraZeneca-Shenzhen University Joint Institute of Nephrology, Shenzhen University Health Science Center, Shenzhen University, China (X.L.).

Ewout J Hoorn (EJ)

Division of Nephrology and Transplantation, Department of Internal Medicine (D.M.B., E.U., E.J.H.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Don Foster (D)

Alnylam Pharmaceuticals, Cambridge, MA (I.Z., J.B.K., S.H., L.M., D.F.).

A H Jan Danser (AHJ)

Division of Vascular Medicine and Pharmacology (D.M.B., L.R., E.U., R.v.V., I.M.G., A.H.J.D.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Angiotensine-II › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Angiotensinogène › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Eucaryotes › Animaux › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antihypertenseurs › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Pression artérielle › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Imino-acides › Proline › Captopril › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Système digestif › Foie › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Tétrazoles › Losartan › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Renoprotective Effects of Small Interfering...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Système rénine-angiotensine › Renoprotective Effects of Small Interfering...