Twin-twin transfusion syndrome is associated with alterations in the metabolic profile of maternal plasma in early gestation: a pilot study.
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
22
01
2021
received:
04
08
2020
pubmed:
16
3
2021
medline:
17
12
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
Twin-twin transfusion syndrome (TTTS) causes perinatal mortality and morbidity in monochorionic twins. The early recognition of and interventional therapy for TTTS is associated with a more favorable overall prognosis. However, the prediction by the use of ultrasound in the first trimester has relatively poor sensitivity and specificity. This study aimed to identify metabolic biomarkers to aid in ultrasound screening of TTTS. Maternal plasma was prospectively collected between 11 and 15 weeks of gestation in apparently uncomplicated monochorionic-diamniotic twin pregnancies. This cohort was divided into: (i) patients who were subsequently diagnosed with TTTS by using ultrasound; (ii) uncomplicated matched controls. Metabolome was profiled by using gas chromatography-mass spectrometry. The levels of fatty acids, organic acids, oxaloacetic acid, and beta-alanine were significantly lower in the TTTS maternal plasma at 11-15 weeks of gestation, and methionine and glycine were also higher (p < 0.05, FDR<0.12). Generally, in TTTS pregnancies, the metabolisms of amino acid, carbohydrate, cofactors, vitamins, and purine were "down-regulated"; whereas bile secretion and pyrimidine metabolism were "upregulated." The metabolomics scanning of early gestation maternal plasma may identify those pregnancies that subsequently develop TTTS; in particular, downregulated fatty acid levels may be biologically plausible to be implicated in the pathogenesis of TTTS.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1080-1088Subventions
Organisme : National Key R&D Program of China
ID : 2018YFC1002900
Organisme : Chongqing Science and Technology Commission
ID : cstc2017jcyjBX0045
Organisme : National Natural Science Foundation of China
ID : 81520108013
Organisme : National Natural Science Foundation of China
ID : 81771613, 81671527
Organisme : Chongqing Health Committee
ID : 2020MSXM037
Organisme : Chongqing Health Committee
ID : 2019GDRC012
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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