Abuse of nutmeg seeds: Detectable by means of liquid chromatography-mass spectrometry techniques?
Allylbenzene Derivatives
/ analysis
Chromatography, Liquid
/ methods
Dioxolanes
/ analysis
Gas Chromatography-Mass Spectrometry
Humans
Mass Spectrometry
/ methods
Myristica
/ chemistry
Oils, Volatile
/ analysis
Psychotropic Drugs
/ chemistry
Pyrogallol
/ analogs & derivatives
Retrospective Studies
Safrole
/ analysis
Seeds
Substance Abuse Detection
/ methods
Substance-Related Disorders
/ diagnosis
GC-MS
LC-HRMS/MS
LC-LIT-MSn
metabolism
nutmeg
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
09
03
2021
received:
25
01
2021
accepted:
10
03
2021
pubmed:
16
3
2021
medline:
29
12
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
Numerous case reports of intoxications with nutmeg seeds (Myristica fragrans, Houtt.) can be found in literature often following their abuse, as psychotropic effects were described after ingestions of large doses. The successful detection of the main ingredients of the nutmeg seeds essential oil elemicin, myristicin, and safrole, as well as their metabolites in human urine by gas chromatography coupled to mass spectrometry (GC-MS) was already described. The aim of this study was to investigate the detectability of the main ingredients of nutmeg seeds and their metabolites in human blood and urine samples using liquid chromatography coupled to linear ion trap mass spectrometry (LC-LIT-MS
Substances chimiques
Allylbenzene Derivatives
0
Dioxolanes
0
Oils, Volatile
0
Psychotropic Drugs
0
Pyrogallol
01Y4A2QXY0
myristicin
04PD6CT78W
elemicin
487-11-6
Safrole
RSB34337V9
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1440-1444Informations de copyright
© 2021 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.
Références
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