Lea Wagmann

Affiliations

Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany.

Publications (52)

Analysis of α- and β-amanitin in Human Plasma at Subnanogram per Milliliter Levels by Reversed Phase Ultra-High Performance Liquid Chromatography Coupled to Orbitrap Mass Spectrometry.

Toxins

Avec: Thomas P Bambauer , Lea Wagmann , Armin A Weber , Markus R Meyer

Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding.

Drug testing and analysis

Avec: Tanja M Gampfer , Lilian H J Richter , Jan Schäper , Lea Wagmann , Markus R Meyer

In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures.

Analytical and bioanalytical chemistry

Avec: Lea Wagmann , Lilian H J Richter , Tobias Kehl , Franziska Wack , Madeleine Pettersson Bergstrand , Simon D Brandt , Alexander Stratford , Hans H Maurer , Markus R Meyer

Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD).

Neuropharmacology

Avec: Adam L Halberstadt , Muhammad Chatha , Adam K Klein , John D McCorvy , Markus R Meyer , Lea Wagmann , Alexander Stratford , Simon D Brandt

Toxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts.

Archives of toxicology

Avec: Sascha K Manier , Lea Wagmann , Veit Flockerzi , Markus R Meyer

Can the Intake of a Synthetic Tryptamine be Detected Only by Blood Plasma Analysis? A Clinical Toxicology Case Involving 4-HO-MET.

Journal of analytical toxicology

Avec: Lea Wagmann , Sascha K Manier , Markus R Meyer

Simultaneous analysis of antihyperglycemic small molecule drugs and peptide drugs by means of dual liquid chromatography high-resolution mass spectrometry.

Clinical chemistry and laboratory medicine

Avec: Aline C Vollmer , Lea Wagmann , Armin A Weber , Markus R Meyer

How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae.

Frontiers in chemistry

Avec: Lea Wagmann , Fabian Frankenfeld , Yu Mi Park , Jennifer Herrmann , Svenja Fischmann , Folker Westphal , Rolf Müller , Veit Flockerzi , Markus R Meyer

Method development for quantitative determination of seven statins including four active metabolites by means of high-resolution tandem mass spectrometry applicable for adherence testing and therapeutic drug monitoring.

Clinical chemistry and laboratory medicine

Avec: Lea Wagmann , Selina Hemmer , Achim T Caspar , Markus R Meyer

Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases.

Drug testing and analysis

Avec: Lea Wagmann , Simon D Brandt , Alexander Stratford , Hans H Maurer , Markus R Meyer

Comparison of Three Untargeted Data Processing Workflows for Evaluating LC-HRMS Metabolomics Data.

Metabolites

Avec: Selina Hemmer , Sascha K Manier , Svenja Fischmann , Folker Westphal , Lea Wagmann , Markus R Meyer

Clinical Toxicological Follow-Up Analysis of a Suicide Attempt Using Chloroquine.

Journal of analytical toxicology

Avec: Cathy M Jacobs , Lea Wagmann , Fabian Frankenfeld , Markus R Meyer

Closing the gap - development of an analytical methodology using volumetric absorptive microsampling of finger prick blood followed by LC-HRMS/MS for adherence monitoring of antihypertensive drugs.

Analytical and bioanalytical chemistry

Avec: Cathy M Jacobs , Michael Kunz , Felix Mahfoud , Lea Wagmann , Markus R Meyer

In vitro metabolic fate of the synthetic cannabinoid receptor agonists (quinolin-8-yl 4-methyl-3-(morpholine-4-sulfonyl)benzoate [QMMSB]) and (quinolin-8-yl 4-methyl-3-((propan-2-yl)sulfamoyl)benzoate [QMiPSB]) including isozyme mapping and carboxylesterases activity testing.

Drug testing and analysis

Avec: Matthias J Richter , Lea Wagmann , Pierce V Kavanagh , Simon D Brandt , Markus R Meyer

In Vitro and In Vivo Toxicometabolomics of the Synthetic Cathinone PCYP Studied by Means of LC-HRMS/MS.

Metabolites

Avec: Selina Hemmer , Lea Wagmann , Benedikt Pulver , Folker Westphal , Markus R Meyer

Studying drug excretion into exhaled breath aerosol - A workflow based on an impaction sampling device and LC-HRMS/MS analysis.

Analytica chimica acta

Avec: Juel Maalouli Schaar , Michael Kunz , Lea Wagmann , Olof Beck , Felix Mahfoud , Markus R Meyer

In vitro glucuronidation of designer benzodiazepines by human UDP-glucuronyltransferases.

Drug testing and analysis

Avec: Madeleine Pettersson Bergstrand , Lilian H J Richter , Hans H Maurer , Lea Wagmann , Markus R Meyer

Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine.

Archives of toxicology

Avec: Tanja M Gampfer , Lea Wagmann , Yu Mi Park , Annelies Cannaert , Jennifer Herrmann , Svenja Fischmann , Folker Westphal , Rolf Müller , Christophe P Stove , Markus R Meyer

Development and application of a strategy for analyzing eight biomarkers in human urine to verify toxic mushroom or ricinus communis ingestions by means of hydrophilic interaction LC coupled to HRMS/MS.

Talanta

Avec: Thomas P Bambauer , Lea Wagmann , Hans H Maurer , Armin A Weber , Markus R Meyer

Abuse of nutmeg seeds: Detectable by means of liquid chromatography-mass spectrometry techniques?

Drug testing and analysis

Avec: Sascha K Manier , Lea Wagmann , Armin A Weber , Markus R Meyer

Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam.

Journal of analytical toxicology

Avec: Lea Wagmann , Sascha K Manier , Christina Felske , Tanja M Gampfer , Matthias J Richter , Niels Eckstein , Markus R Meyer

Liquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes.

Metabolites

Avec: Sascha K Manier , Florian Schwermer , Lea Wagmann , Niels Eckstein , Markus R Meyer

In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity.

Metabolites

Avec: Matthias J Richter , Lea Wagmann , Tanja M Gampfer , Simon D Brandt , Markus R Meyer

New Psychoactive Substances: Which Biological Matrix Is the Best for Clinical Toxicology Screening?

Therapeutic drug monitoring

Avec: Lea Wagmann , Cathy M Jacobs , Markus R Meyer

Efficacy of Antihypertensive Drugs of Different Classes After Renal Denervation in Spontaneously Hypertensive Rats.

Hypertension (Dallas, Tex. : 1979)

Avec: Mathias Hohl , Lucas Lauder , Özlem Sevimli , Mert Tokcan , Lea Wagmann , Felix Götzinger , Clara Schneider , Ulrich Hübner , Ulrike Lehnert , Markus R Meyer , Michael Böhm , Felix Mahfoud

Sample Matrices for Mass Spectrometry-Based Adherence Monitoring: A Systematic Critical Review.

Therapeutic drug monitoring

Avec: Cathy M Jacobs , Lea Wagmann , Markus R Meyer

Prevalence of Drugs of Abuse and Cognitive Enhancer Consumption Monitored in Grab Samples and Composite Wastewater via Orbitrap Mass Spectrometry Analysis.

Molecules (Basel, Switzerland)

Avec: Fabian Frankenfeld , Lea Wagmann , Cathy M Jacobs , Markus R Meyer

Evaluation and analytical applicability of a novel volumetric absorptive microsampling strategy for adherence monitoring of antihypertensive drugs by means of LC-HRMS/MS.

Analytica chimica acta

Avec: Cathy M Jacobs , Michael Kunz , Felix Mahfoud , Lea Wagmann , Markus R Meyer

Recent trends in drugs of abuse metabolism studies for mass spectrometry-based analytical screening procedures.

Analytical and bioanalytical chemistry

Avec: Lea Wagmann , Tanja M Gampfer , Markus R Meyer

Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis.

Molecules (Basel, Switzerland)

Avec: Lea Wagmann , Aline C Vollmer , Lucas Lauder , Felix Mahfoud , Markus R Meyer

Altered metabolic pathways elucidated via untargeted in vivo toxicometabolomics in rat urine and plasma samples collected after controlled application of a human equivalent amphetamine dose.

Archives of toxicology

Avec: Selina Hemmer , Lea Wagmann , Markus R Meyer

Further development of a liquid chromatography-high-resolution mass spectrometry/mass spectrometry-based strategy for analyzing eight biomarkers in human urine indicating toxic mushroom or Ricinus communis ingestions.

Drug testing and analysis

Avec: Thomas P Bambauer , Lea Wagmann , Armin A Weber , Markus R Meyer

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models.

Scientific reports

Avec: Philip Schippers , Sari Rasheed , Yu Mi Park , Timo Risch , Lea Wagmann , Selina Hemmer , Sascha K Manier , Rolf Müller , Jennifer Herrmann , Markus R Meyer

Analytical toxicology of yew constituents in human blood and urine by liquid chromatography-high-resolution tandem mass spectrometry.

Drug testing and analysis

Avec: Cathy M Jacobs , Lea Wagmann , Markus R Meyer

A simplified strategy to assess the cytotoxicity of new psychoactive substances in HepG2 cells using a high content screening assay - Exemplified for nine compounds.

Toxicology

Avec: Tanja M Gampfer , Lea Wagmann , Benedikt Pulver , Folker Westphal , Veit Flockerzi , Markus R Meyer

Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma.

Metabolomics : Official journal of the Metabolomic Society

Avec: Selina Hemmer , Sascha K Manier , Lea Wagmann , Markus R Meyer

Metabolism and cytotoxicity studies of the two hallucinogens 1cP-LSD and 4-AcO-DET in human liver and zebrafish larvae models using LC-HRMS/MS and a high-content screening assay.

Journal of pharmaceutical and biomedical analysis

Avec: Tanja M Gampfer , Victoria Schütz , Philip Schippers , Sari Rasheed , Jonas Baumann , Lea Wagmann , Benedikt Pulver , Folker Westphal , Veit Flockerzi , Rolf Müller , Markus R Meyer

Impact of four different extraction methods and three different reconstitution solvents on the untargeted metabolomics analysis of human and rat urine samples.

Journal of chromatography. A

Avec: Selina Hemmer , Sascha K Manier , Lea Wagmann , Markus R Meyer

Rapid analysis of amatoxins in human urine by means of affinity column chromatography and liquid chromatography-high-resolution tandem mass spectrometry.

Scientific reports

Avec: Aline C Vollmer , Claudia Fecher-Trost , Candace S Bever , Christina C Tam , Lea Wagmann , Markus R Meyer

Toxicokinetic Studies and Analytical Toxicology of the New Synthetic Opioids Cyclopentanoyl-Fentanyl and Tetrahydrofuranoyl-Fentanyl.

Journal of analytical toxicology

Avec: Tanja M Gampfer , Lea Wagmann , Matthias J Richter , Svenja Fischmann , Folker Westphal , Markus R Meyer

Toxicokinetics and Analytical Toxicology of Flualprazolam: Metabolic Fate, Isozyme Mapping, Human Plasma Concentration and Main Urinary Excretion Products.

Journal of analytical toxicology

Avec: Lea Wagmann , Sascha K Manier , Thomas P Bambauer , Christina Felske , Niels Eckstein , Veit Flockerzi , Markus R Meyer

Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.

Toxicology letters

Avec: Lilian H J Richter , Jennifer Herrmann , Anastasia Andreas , Yu Mi Park , Lea Wagmann , Veit Flockerzi , Rolf Müller , Markus R Meyer

Phenethylamine-derived new psychoactive substances 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings.

Drug testing and analysis

Avec: Lea Wagmann , Nora Hempel , Lilian H J Richter , Simon D Brandt , Alexander Stratford , Markus R Meyer

Development, validation, and application of a quantitative volumetric absorptive microsampling-based method in finger prick blood by means of LC-HRMS/MS applicable for adherence monitoring of antipsychotics.

Analytical and bioanalytical chemistry

Avec: Cathy M Jacobs , Lea Wagmann , Markus R Meyer

Cytotoxicity, metabolism, and isozyme mapping of the synthetic cannabinoids JWH-200, A-796260, and 5F-EMB-PINACA studied by means of in vitro systems.

Archives of toxicology

Avec: Tanja M Gampfer , Lea Wagmann , Anouar Belkacemi , Veit Flockerzi , Markus R Meyer

Toxic plants-Detection of colchicine in a fast systematic clinical toxicology screening using liquid chromatography-mass spectrometry.

Drug testing and analysis

Avec: Aline C Vollmer , Lea Wagmann , Markus R Meyer

In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists 2F-QMPSB and SGT-233 Including Isozyme Mapping and Carboxylesterases Activity Testing.

Journal of analytical toxicology

Avec: Matthias J Richter , Lea Wagmann , Simon D Brandt , Markus R Meyer

Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases.

Archives of toxicology

Avec: Lea Wagmann , Rebecca G Stiller , Svenja Fischmann , Folker Westphal , Markus R Meyer

Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS-method development, validation, comparison of four sample matrices, and proof of concept.

Analytical and bioanalytical chemistry

Avec: Cathy M Jacobs , Julia C Radosa , Lea Wagmann , Julia S M Zimmermann , Askin C Kaya , Aylin Aygün , Tatjana Edel , Lisa Stotz , Mohamed Ismaeil , Erich-Franz Solomayer , Markus R Meyer

Quantitative analysis of drugs of abuse and cognitive enhancers in influent wastewater by means of two chromatographic methods.

Drug testing and analysis

Avec: Fabian Frankenfeld , Lea Wagmann , Cathy M Jacobs , Markus R Meyer

Feedback from the 8th European Bioanalysis Forum Young Scientist Symposium.

Bioanalysis

Avec: Liesl Heughebaert , Adam Williams , Amelia Roberts , Cathy Jacobs , Claire Szuster , Connor Walker , Elien Van Nuffel , Esme Atkin , Francesca Minelli , Kate Groves , Katherine Sime , Katia Zeiser , Michele Protti , Lea Wagmann , Oscar Knight , Robert Stewart , Rosie Penford , Salvatore Calogero , Philip Timmerman

In Vivo and In Vitro Metabolic Fate and Urinary Detectability of Five Deschloroketamine Derivatives Studied by Means of Hyphenated Mass Spectrometry.

Metabolites

Avec: Fabian Frankenfeld , Lea Wagmann , Anush Abelian , Jason Wallach , Adeboye Adejare , Simon D Brandt , Markus R Meyer

Réseau de co-auteurs

Markus R Meyer 51 collaborations

Sascha K Manier 10 collaborations

Cathy M Jacobs 10 collaborations

Tanja M Gampfer 9 collaborations

Simon D Brandt 8 collaborations

Folker Westphal 8 collaborations

Veit Flockerzi 7 collaborations

Selina Hemmer 7 collaborations

Armin A Weber 5 collaborations

Lilian H J Richter 5 collaborations

Fabian Frankenfeld 5 collaborations

Svenja Fischmann 5 collaborations

Rolf Müller 5 collaborations

Felix Mahfoud 5 collaborations

Matthias J Richter 5 collaborations

Thomas P Bambauer 4 collaborations

Alexander Stratford 4 collaborations

Hans H Maurer 4 collaborations

Aline C Vollmer 4 collaborations

Yu Mi Park 4 collaborations

Jennifer Herrmann 4 collaborations

Michael Kunz 3 collaborations

Benedikt Pulver 3 collaborations

Niels Eckstein 3 collaborations

Madeleine Pettersson Bergstrand 2 collaborations

Christina Felske 2 collaborations

Lucas Lauder 2 collaborations

Philip Schippers 2 collaborations

Sari Rasheed 2 collaborations

Jan Schäper 1 collaboration

Tobias Kehl 1 collaboration

Franziska Wack 1 collaboration

Adam L Halberstadt 1 collaboration

Muhammad Chatha 1 collaboration

Adam K Klein 1 collaboration

John D McCorvy 1 collaboration

Achim T Caspar 1 collaboration

Pierce V Kavanagh 1 collaboration

Juel Maalouli Schaar 1 collaboration

Olof Beck 1 collaboration

Annelies Cannaert 1 collaboration

Christophe P Stove 1 collaboration

Florian Schwermer 1 collaboration

Mathias Hohl 1 collaboration

Özlem Sevimli 1 collaboration

Mert Tokcan 1 collaboration

Felix Götzinger 1 collaboration

Clara Schneider 1 collaboration

Ulrich Hübner 1 collaboration

Ulrike Lehnert 1 collaboration

Michael Böhm 1 collaboration

Timo Risch 1 collaboration

Victoria Schütz 1 collaboration

Jonas Baumann 1 collaboration

Claudia Fecher-Trost 1 collaboration

Candace S Bever 1 collaboration

Christina C Tam 1 collaboration

Anastasia Andreas 1 collaboration

Nora Hempel 1 collaboration

Anouar Belkacemi 1 collaboration

Rebecca G Stiller 1 collaboration

Julia C Radosa 1 collaboration

Julia S M Zimmermann 1 collaboration

Askin C Kaya 1 collaboration

Aylin Aygün 1 collaboration

Tatjana Edel 1 collaboration

Lisa Stotz 1 collaboration

Mohamed Ismaeil 1 collaboration

Erich-Franz Solomayer 1 collaboration

Liesl Heughebaert 1 collaboration

Adam Williams 1 collaboration

Amelia Roberts 1 collaboration

Cathy Jacobs 1 collaboration

Claire Szuster 1 collaboration

Connor Walker 1 collaboration

Elien Van Nuffel 1 collaboration

Esme Atkin 1 collaboration

Francesca Minelli 1 collaboration

Kate Groves 1 collaboration

Katherine Sime 1 collaboration

Katia Zeiser 1 collaboration

Michele Protti 1 collaboration

Oscar Knight 1 collaboration

Robert Stewart 1 collaboration

Rosie Penford 1 collaboration

Salvatore Calogero 1 collaboration

Philip Timmerman 1 collaboration

Anush Abelian 1 collaboration

Jason Wallach 1 collaboration

Adeboye Adejare 1 collaboration