Phenethylamine-derived new psychoactive substances 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings.
LC−HRMS/MS
drugs of abuse
metabolism
new psychoactive substances
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
15
05
2019
revised:
05
07
2019
accepted:
07
07
2019
pubmed:
13
7
2019
medline:
27
2
2020
entrez:
13
7
2019
Statut:
ppublish
Résumé
Psychoactive substances of the 2C-series are phenethylamine-based designer drugs that can induce psychostimulant and hallucinogenic effects. The so-called 2C-FLY series contains rigidified methoxy groups integrated in a 2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran core. The aim of the presented work was to investigate the in vivo and in vitro metabolic fate including isoenzyme activities and toxicological detectability of the three new psychoactive substances (NPS) 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY to allow clinical and forensic toxicologists the identification of these novel compounds. Rat urine, after oral administration, and pooled human liver S9 fraction (pS9) incubations were analyzed by liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS). By performing activity screenings, the human isoenzymes involved were identified and toxicological detectability in rat urine investigated using standard urine screening approaches (SUSAs) based on gas chromatography (GC)-MS, LC-MS
Substances chimiques
Designer Drugs
0
Phenethylamines
0
Psychotropic Drugs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1507-1521Subventions
Organisme : Armin A. Weber
Organisme : Hans H. Maurer
Organisme : Gabriele Ulrich
Informations de copyright
© 2019 The Authors Drug Testing and Analysis Published by John Wiley & Sons Ltd.
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