Genetic and immunological basis of human African trypanosomiasis.
Adaptive Immunity
Apolipoprotein L1
/ genetics
Disease Resistance
/ genetics
Disease Susceptibility
/ immunology
Gene Expression Regulation
Genetic Predisposition to Disease
Genetic Variation
Host-Parasite Interactions
/ genetics
Humans
Immunity, Innate
Membrane Glycoproteins
/ genetics
Protein Binding
Protozoan Proteins
/ genetics
Trypanosoma brucei gambiense
/ immunology
Trypanosomiasis, African
/ etiology
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
16
01
2021
revised:
11
02
2021
accepted:
19
02
2021
pubmed:
16
3
2021
medline:
11
3
2022
entrez:
15
3
2021
Statut:
ppublish
Résumé
Human African trypanosomiasis, or sleeping sickness, results from infection by two subspecies of the protozoan flagellate parasite Trypanosoma brucei, termed Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, prevalent in western and eastern Africa respectively. These subspecies escape the trypanolytic potential of human serum, which efficiently acts against the prototype species Trypanosoma brucei brucei, responsible for the Nagana disease in cattle. We review the various strategies and components used by trypanosomes to counteract the immune defences of their host, highlighting the adaptive genomic evolution that occurred in both parasite and host to take the lead in this battle. The main parasite surface antigen, named Variant Surface Glycoprotein or VSG, appears to play a key role in different processes involved in the dialogue with the host.
Identifiants
pubmed: 33721725
pii: S0952-7915(21)00017-0
doi: 10.1016/j.coi.2021.02.007
pmc: PMC8589022
pii:
doi:
Substances chimiques
APOL1 protein, human
0
Apolipoprotein L1
0
Membrane Glycoproteins
0
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-20Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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