A hepatitis B virus causes chronic infections in equids worldwide.
Animals
Antibodies, Viral
/ isolation & purification
Antiviral Agents
/ pharmacology
Cell Line, Tumor
Cells, Cultured
Coinfection
/ drug therapy
DNA, Viral
/ isolation & purification
Disease Models, Animal
Drug Evaluation, Preclinical
/ methods
Equidae
/ virology
Female
Hepacivirus
/ genetics
Hepatitis B virus
/ genetics
Hepatitis B, Chronic
/ blood
Hepatitis C
/ drug therapy
Hepatocytes
Humans
Liver
/ immunology
Primary Cell Culture
Virus Internalization
HBV
animal model
coinfection
equids
evolution
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
30 03 2021
30 03 2021
Historique:
entrez:
16
3
2021
pubmed:
17
3
2021
medline:
25
2
2023
Statut:
ppublish
Résumé
Preclinical testing of novel therapeutics for chronic hepatitis B (CHB) requires suitable animal models. Equids host homologs of hepatitis C virus (HCV). Because coinfections of hepatitis B virus (HBV) and HCV occur in humans, we screened 2,917 specimens from equids from five continents for HBV. We discovered a distinct HBV species (Equid HBV, EqHBV) in 3.2% of donkeys and zebras by PCR and antibodies against EqHBV in 5.4% of donkeys and zebras. Molecular, histopathological, and biochemical analyses revealed that infection patterns of EqHBV resembled those of HBV in humans, including hepatotropism, moderate liver damage, evolutionary stasis, and potential horizontal virus transmission. Naturally infected donkeys showed chronic infections resembling CHB with high viral loads of up to 2.6 × 10
Identifiants
pubmed: 33723007
pii: 2013982118
doi: 10.1073/pnas.2013982118
pmc: PMC8020657
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Antiviral Agents
0
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Alvaro Aguilar-Setien
(A)
Walid Azab
(W)
Augusto Carluccio
(A)
Dimo Dietrich
(D)
Carlos Roberto Franke
(CR)
Ignacio García-Bocanegra
(I)
Fernando García-Lacy
(F)
Lara M Jeworoski
(LM)
Jörg Jores
(J)
Ramona Kepper
(R)
Eduardo Martins Netto
(EM)
Ellis Owusu-Dabo
(E)
Jorge R L Ribas
(JRL)
Christina Roncoroni
(C)
Pia L Roppert
(PL)
Anton Rusenov
(A)
Nikolina Rusenova
(N)
Nikolay Sandev
(N)
Peter A Seeber
(PA)
Anat Shnaiderman-Torban
(A)
Amir Steinman
(A)
Birthe Tegtmeyer
(B)
Vincenzo Veneziano
(V)
Maria C Veronesi
(MC)
Stephanie Walter
(S)
Dimitrinka Zapryanova
(D)
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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