Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe.
3D reconstructions
cerebral cortex
dendrites
intracellular injections
layer III
layer V
spines
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
05 07 2021
05 07 2021
Historique:
received:
10
11
2020
revised:
03
02
2021
accepted:
04
02
2021
pubmed:
17
3
2021
medline:
8
3
2022
entrez:
16
3
2021
Statut:
ppublish
Résumé
Pyramidal neurons are the most abundant and characteristic neuronal type in the cerebral cortex and their dendritic spines are the main postsynaptic elements of cortical excitatory synapses. Previous studies have shown that pyramidal cell structure differs across layers, cortical areas, and species. However, within the human cortex, the pyramidal dendritic morphology has been quantified in detail in relatively few cortical areas. In the present work, we performed intracellular injections of Lucifer Yellow at several distances from the temporal pole. We found regional differences in pyramidal cell morphology, which showed large inter-individual variability in most of the morphological variables measured. However, some values remained similar in all cases. The smallest and least complex cells in the most posterior temporal region showed the greatest dendritic spine density. Neurons in the temporal pole showed the greatest sizes with the highest number of spines. Layer V cells were larger, more complex, and had a greater number of dendritic spines than those in layer III. The present results suggest that, while some aspects of pyramidal structure are conserved, there are specific variations across cortical regions, and species.
Identifiants
pubmed: 33723567
pii: 6172085
doi: 10.1093/cercor/bhab034
pmc: PMC8258433
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3592-3609Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : PGC2018-094307-B-I00
Organisme : Cajal Blue Brain Project
Organisme : Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
ID : CB06/05/0066
Organisme : European Union's Horizon 2020 Framework Programme for Research and Innovation
ID : 785907
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
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