Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A

Adenosine A1 Receptor Antagonists / chemical synthesis Bridged Bicyclo Compounds / chemistry Drug Design Fluorescence Resonance Energy Transfer Fluorescent Dyes / chemistry HEK293 Cells Humans Kinetics Ligands Octanes / chemistry Receptor, Adenosine A1 / chemistry Structure-Activity Relationship Xanthine / chemistry

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
27 05 2021
Historique:
pubmed: 17 3 2021
medline: 22 6 2021
entrez: 16 3 2021
Statut: ppublish

Résumé

The adenosine A

Identifiants

DOI: 10.1021/acs.jmedchem.0c02067 PMID: 33724031
pubmed: 33724031
doi: 10.1021/acs.jmedchem.0c02067
doi:

Substances chimiques

Adenosine A1 Receptor Antagonists 0
Bridged Bicyclo Compounds 0
Fluorescent Dyes 0
Ligands 0
Octanes 0
Receptor, Adenosine A1 0
bicyclo(2.2.2)octane 0
Xanthine 1AVZ07U9S7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6670-6695

Subventions

Organisme : Medical Research Council
ID : MR/N020081/1
Pays : United Kingdom

Auteurs

Eleonora Comeo (E)

Medicinal Chemistry, Monash University, Parkville, Victoria 3052, Australia.
Division of Biomolecular Sciences and Medicinal Chemistry, School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, B15 2TT and University of Nottingham, Birmingham NG7 2UH, United Kingdom.

Phuc Trinh (P)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Anh T Nguyen (AT)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Cameron J Nowell (CJ)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Nicholas D Kindon (ND)

Division of Biomolecular Sciences and Medicinal Chemistry, School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, B15 2TT and University of Nottingham, Birmingham NG7 2UH, United Kingdom.

Mark Soave (M)

Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, B15 2TT and University of Nottingham, Birmingham NG7 2UH, United Kingdom.

Leigh A Stoddart (LA)

Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, B15 2TT and University of Nottingham, Birmingham NG7 2UH, United Kingdom.

Jonathan M White (JM)

School of Chemistry and the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia.
ORCID: 0000-0002-0707-6257

Stephen J Hill (SJ)

Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, B15 2TT and University of Nottingham, Birmingham NG7 2UH, United Kingdom.
ORCID: 0000-0002-4424-239X

Barrie Kellam (B)

Division of Biomolecular Sciences and Medicinal Chemistry, School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, B15 2TT and University of Nottingham, Birmingham NG7 2UH, United Kingdom.
ORCID: 0000-0003-0030-9908

Michelle L Halls (ML)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Lauren T May (LT)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Peter J Scammells (PJ)

Medicinal Chemistry, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0003-2930-895X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P1 › Antagonistes du récepteur A1 à l'adénosine › Development and Application of...
questionsmedicales.fr › Composés polycycliques › Composés pontés › Composés bicycliques pontés › Development and Application of...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Development and Application of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Transfert d'énergie par résonance de fluorescence › Development and Application of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Development and Application of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Development and Application of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development and Application of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Development and Application of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Development and Application of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Octanes › Development and Application of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteur A1 à l'adénosine › Development and Application of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Development and Application of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Xanthine › Development and Application of...