Microcephaly Outcomes among Zika Virus-Infected Pregnant Women in Honduras.
Adolescent
Adult
Female
Gestational Age
Honduras
/ epidemiology
Humans
Incidence
Microcephaly
/ complications
Pregnancy
Pregnancy Complications, Infectious
/ diagnosis
Prenatal Diagnosis
/ methods
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Zika Virus
/ genetics
Zika Virus Infection
/ complications
Journal
The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Titre abrégé: Am J Trop Med Hyg
Pays: United States
ID NLM: 0370507
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
17
11
2020
accepted:
19
01
2021
pubmed:
17
3
2021
medline:
17
2
2022
entrez:
16
3
2021
Statut:
epublish
Résumé
The impact of Zika virus (ZIKV) infection on pregnancies shows regional variation emphasizing the importance of studies in different geographical areas. We conducted a prospective study in Tegucigalpa, Honduras, recruiting 668 pregnant women between July 20, 2016, and December 31, 2016. We performed Trioplex real-time reverse transcriptase-PCR (rRT-PCR) in 357 serum samples taken at the first prenatal visit. The presence of ZIKV was confirmed in seven pregnancies (7/357, 2.0%). Nine babies (1.6%) had microcephaly (head circumference more than two SDs below the mean), including two (0.3%) with severe microcephaly (head circumference [HC] more than three SDs below the mean). The mothers of both babies with severe microcephaly had evidence of ZIKV infection. A positive ZIKV Trioplex rRT-PCR was associated with a 33.3% (95% CI: 4.3-77.7%) risk of HC more than three SDs below the mean.
Identifiants
pubmed: 33724927
doi: 10.4269/ajtmh.20-1483
pmc: PMC8103474
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1737-1740Subventions
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States