A Systematic Review on the Genotoxic Effects of Selective Serotonin Reuptake Inhibitors.

Citalopram DNA Damage Diabetes Mellitus, Type 2 Humans Paroxetine Selective Serotonin Reuptake Inhibitors / adverse effects
Antidepressants DNA damage Genotoxicity SSRIs

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2021
Historique:
entrez: 16 3 2021
pubmed: 17 3 2021
medline: 19 3 2021
Statut: ppublish

Résumé

Depression is a mental disorder and a major public health concern affecting millions of people worldwide. It is a common disorder that has been associated with several medical comorbidities often linked with aging, such as dementia, type II diabetes, cardiovascular and cerebrovascular diseases, as well as metabolic syndrome. There are a variety of medications available for depression treatment. Selective serotonin reuptake inhibitors (SSRIs) are one of the antidepressant drug classes that are most widely used to treat depressive disorders and depressive symptoms in other diseases. Due to many contradictory findings on the adverse effects and toxicities of SSRIs (especially genotoxicities), we reviewed the genotoxic effects of these drugs. Based on the guidelines proposed in the PRISMA statement, we performed a systematic review by searching international electronic databases including PubMed, Scopus, Embase, and Web of Science to find the published documents on SSRIs and their genotoxic effects from January 1990 to November 2019. After the removal of 203 duplicate articles, 385 articles were screened and 167 articles met the inclusion criteria and qualified for evaluation of their full texts. After this, 26 articles were appropriate for final review. This revealed that the proportion of genotoxicities was highest for citalopram and fluoxetine, with a smaller proportion for sertraline. Limited documentations showed genotoxic and partial genotoxic effects for paroxetine and escitalopram, respectively. Although a number of studies have found genotoxic effects of SSRIs, there are also some factors including doses, duration of exposure, model of experiments, and the type of technique assay that may affect the results.

Identifiants

DOI: 10.1007/978-3-030-55035-6_8 PMID: 33725349
pubmed: 33725349
doi: 10.1007/978-3-030-55035-6_8
doi:

Substances chimiques

Serotonin Uptake Inhibitors 0
Citalopram 0DHU5B8D6V
Paroxetine 41VRH5220H

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

115-124

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Auteurs

Mahnaz Ahmadimanesh (M)

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Food and Drug Vice Presidency, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohammad Reza Abbaszadegan (MR)

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Genetics Research Center, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Narges Hedayati (N)

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Rezvan Yazdian-Robati (R)

Molecular and Cell biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. R.yazdian@mazums.ac.ir.

Tannaz Jamialahmadi (T)

Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Amirhossein Sahebkar (A)

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
Polish Mothers Memorial Hospital Research Institute (PMMHRI), Mashhad, Iran. amir_saheb2000@yahoo.com.

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