Quantification of immobilization-induced changes in human calf muscle using speed-of-sound ultrasound: An observational pilot study.
Adult
Aged
Casts, Surgical
/ adverse effects
Female
Humans
Leg
/ diagnostic imaging
Leg Injuries
/ diagnostic imaging
Male
Middle Aged
Muscle, Skeletal
/ diagnostic imaging
Muscular Atrophy
/ diagnostic imaging
Pilot Projects
Prospective Studies
Reproducibility of Results
Restraint, Physical
/ adverse effects
Sound
Ultrasonography
/ methods
Young Adult
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
19 Mar 2021
19 Mar 2021
Historique:
received:
19
04
2020
accepted:
05
11
2020
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
23
3
2021
Statut:
ppublish
Résumé
Short-term immobilization leads to fatty muscular degeneration, which is associated with various negative health effects. Based on literature showing very high correlations between MRI Dixon fat fraction and Speed-of-Sound (SoS), we hypothesized that we can detect short-term-immobilization-induced differences in SoS.Both calves of 10 patients with a calf cast on one side for a mean duration of 41 ± 26 days were examined in relaxed position using a standard ultrasound machine. Calf perimeters were measured for both sides. A flat Plexiglas-reflector, placed vertically on the opposite side of the probe with the calf in-between, was used as a timing reference for SoS. SoS was both manually annotated by two readers and assessed by an automatic annotation algorithm. The thickness values of the subcutaneous fat and muscle layers were manually read from the B-mode images. Differences between the cast and non-cast calves were calculated with a paired t test. Correlation analysis of SoS and calf perimeter was performed using Pearson's correlation coefficient.Paired t test showed significant differences between the cast and non-cast side for both SoS (P < .01) and leg perimeter (P < .001). SoS was reduced with the number of days after cast installment (r = -0.553, P = .097). No significant differences were found for muscle layer thickness, subcutaneous fat layer thickness, mean fat echo intensity, or mean muscle echo intensity.Short-term-immobilization led to a significant reduction in SoS in the cast calf compared to the healthy calf, indicating a potential role of SoS as a biomarker in detecting immobilization-induced fatty muscular degeneration not visible on B-mode ultrasound.
Identifiants
pubmed: 33725923
doi: 10.1097/MD.0000000000023576
pii: 00005792-202103190-00004
pmc: PMC7982197
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23576Subventions
Organisme : Swiss National Science Foundation
ID : 179116
Pays : Switzerland
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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