Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) coinfection: A unique case series.
Adrenal Cortex Hormones
/ therapeutic use
Adult
Aged
COVID-19
/ epidemiology
Coinfection
/ drug therapy
Coronavirus Infections
/ drug therapy
Diabetes Mellitus
/ epidemiology
Female
Heart Failure
/ epidemiology
Humans
Intensive Care Units
Length of Stay
/ statistics & numerical data
Male
Middle Aged
Middle East Respiratory Syndrome Coronavirus
/ isolation & purification
Obesity
/ epidemiology
SARS-CoV-2
/ isolation & purification
COVID-19 Drug Treatment
COVID-19
Coinfection
MERS-CoV
Middle East Respiratory Syndrome Coronavirus
SARS-CoV-2
Journal
Travel medicine and infectious disease
ISSN: 1873-0442
Titre abrégé: Travel Med Infect Dis
Pays: Netherlands
ID NLM: 101230758
Informations de publication
Date de publication:
Historique:
received:
17
01
2021
revised:
26
02
2021
accepted:
09
03
2021
pubmed:
18
3
2021
medline:
20
5
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
The emergence of the Severe Acute Respiratory Syndrome Coroanvirus 2 (SARS-CoV-2) had raised possibilities of coinfection with the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in countries were these two viruses were reported. In this study, we describe the clinical presentation and demographics of eight patients who were coinfected with SARS-CoV-2 and MERS-CoV. This is a case series of hospitalized patients admitted to intensive care units (ICUs). We collected demographics, underlying conditions, presenting symptoms and clinical outcome from the patients' medical records. During the study period from March 14, 2020 to October 19, 2020, there was a total of 67 SARS-CoV-2 ICU admitted patients who underwent simultaneous SARS-CoV-2 and MERS-CoV testing by PCR. Of those patients, 8 (12%) tested positive for both SARS-CoV-2 and MERS-CoV. There were 6 (75%) males, the mean age ± SD was 44.4 ± 11.8 years, and 7 (87.5%) were obese. Of the patients, 7 (87.5%) were non-smokers, 1 (12.5%) had diabetes mellitus, 1 (12.5%) had heart failure, and 1 (12.5%) had been on anti-platelet therapy. The mean hospital length of stay (LOS) was 21.1 ± 11.6 days and the average ICU LOS was 10.9 ± 6.03 days. All patients received supportive therapy and all were treated with corticosteroid. Of all the patients, 4 (50%) were discharged home and 3 (37.5%) died. This case series is an important addition to the medical knowledge as it showed the interaction of the coinfection of SARS-CoV-2 and MERS-CoV.
Identifiants
pubmed: 33727175
pii: S1477-8939(21)00067-3
doi: 10.1016/j.tmaid.2021.102026
pmc: PMC7955802
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102026Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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