Molecular epidemiology of peste des petits ruminants virus in Nigeria: An update.
Morbillivirus
Nigeria
Phylogeny
distribution
genetic diversity
transboundary disease
Journal
Transboundary and emerging diseases
ISSN: 1865-1682
Titre abrégé: Transbound Emerg Dis
Pays: Germany
ID NLM: 101319538
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
04
03
2021
received:
09
09
2020
accepted:
12
03
2021
pubmed:
18
3
2021
medline:
7
5
2022
entrez:
17
3
2021
Statut:
ppublish
Résumé
Peste des petits ruminants (PPR) is a highly contagious viral disease that mainly affects goats and sheep in Asia, Africa and the Middle East. The PPR virus (PPRV) can be classified into four genetically distinct lineages (I, II, III and IV). All have been historically present in Africa, except the Asian lineage IV that has been spreading across the globe and across Africa in recent decades. Previous studies have identified the presence of lineage IV in Nigeria since 2010. In the present study, samples were taken from 429 small ruminants with PPR symptoms across Nigeria in 2017-2020 to provide an update on the distribution and genetic diversity of PPRV in the country. Sequences from a portion of the PPRV nucleoprotein (N) gene were obtained from 91 samples, 90 belonging to lineage IV and one to lineage II. Phylogenetic analysis identified at least four lineage IV sub-clusters in Nigeria, grouping samples across multiple regions. Our results suggest extensive endemic circulation of a wide range of PPRV strains across Nigeria and across borders with neighbouring countries, underlining the difficulty involved in controlling the disease in the region.
Identifiants
pubmed: 33728807
doi: 10.1111/tbed.14073
pmc: PMC9290802
doi:
Banques de données
GENBANK
['MT193239', 'MT193240', 'MT193241', 'MT193242', 'MW600929', 'MW600925', 'MT193243', 'MT193244', 'MT193246', 'MT193237', 'MT193234', 'MT193247', 'MT193248', 'MT193236', 'MT193249', 'MT193238', 'MT193250', 'MT193251', 'MT193252', 'MT193235', 'MT193254', 'MT193255', 'MT193256']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1634-1640Subventions
Organisme : Centre de Coopération Internationale en Recherche Agronomique pour le Développement. France
ID : Grant (SI2.756606)
Organisme : (FOOD/2019/410-957) from the European Union.
Organisme : National Veterinary Research Institute, Vom. Nigeria.
Informations de copyright
© 2021 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.
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