Genomic and healthcare dynamics of nosocomial SARS-CoV-2 transmission.
SARS-CoV-2
genetics
genome
genomics
healthcare worker
healthcare-associated
human
infectious disease
microbiology
nosocomial
sequencing
virus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
17 03 2021
17 03 2021
Historique:
received:
04
12
2020
accepted:
16
03
2021
pubmed:
18
3
2021
medline:
7
4
2021
entrez:
17
3
2021
Statut:
epublish
Résumé
Understanding the effectiveness of infection control methods in reducing and preventing SARS-CoV-2 transmission in healthcare settings is of high importance. We sequenced SARS-CoV-2 genomes for patients and healthcare workers (HCWs) across multiple geographically distinct UK hospitals, obtaining 173 high-quality SARS-CoV-2 genomes. We integrated patient movement and staff location data into the analysis of viral genome data to understand spatial and temporal dynamics of SARS-CoV-2 transmission. We identified eight patient contact clusters (PCC) with significantly increased similarity in genomic variants compared to non-clustered samples. Incorporation of HCW location further increased the number of individuals within PCCs and identified additional links in SARS-CoV-2 transmission pathways. Patients within PCCs carried viruses more genetically identical to HCWs in the same ward location. SARS-CoV-2 genome sequencing integrated with patient and HCW movement data increases identification of outbreak clusters. This dynamic approach can support infection control management strategies within the healthcare setting.
Identifiants
pubmed: 33729154
doi: 10.7554/eLife.65453
pii: 65453
pmc: PMC8009659
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Manchester NIHR Biomedical Research Centre
ID : IS-BRC-1215-20007
Informations de copyright
© 2021, Ellingford et al.
Déclaration de conflit d'intérêts
JE, RG, JM, SA, JE, DG, WN, SB, NM, GB No competing interests declared
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