Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.
Animals
Axons
/ drug effects
Drosophila melanogaster
/ drug effects
Memory Consolidation
/ drug effects
Memory, Long-Term
/ drug effects
Mushroom Bodies
/ drug effects
Nerve Net
/ drug effects
Neuronal Plasticity
/ drug effects
Odorants
Oleic Acids
/ pharmacology
Pheromones
/ pharmacology
Synapses
/ drug effects
Drosophila
Kenyon cell
functional imaging
functional plasticity
memory consolidation
microglomerulus
mushroom body
mushroom body calyx
projection neuron
structural plasticity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
16 03 2021
16 03 2021
Historique:
received:
26
08
2020
revised:
07
01
2021
accepted:
24
02
2021
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain.
Identifiants
pubmed: 33730583
pii: S2211-1247(21)00185-6
doi: 10.1016/j.celrep.2021.108871
pmc: PMC8515896
mid: NIHMS1730948
pii:
doi:
Substances chimiques
11-cis-vaccenyl acetate
0
Oleic Acids
0
Pheromones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108871Subventions
Organisme : NIMH NIH HHS
ID : RF1 MH120679
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Cell. 1994 Oct 7;79(1):35-47
pubmed: 7923375
Elife. 2014 Dec 23;3:e04577
pubmed: 25535793
Cell. 2007 Mar 23;128(6):1187-203
pubmed: 17382886
IEEE Trans Image Process. 1998;7(1):27-41
pubmed: 18267377
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E448-E457
pubmed: 29284750
Nature. 2012 Aug 23;488(7412):512-6
pubmed: 22810589
Science. 1994 Feb 4;263(5147):692-5
pubmed: 8303280
Neuron. 2016 Jul 20;91(2):293-311
pubmed: 27373836
Cell Rep. 2012 Oct 25;2(4):991-1001
pubmed: 23063364
J Comp Neurol. 2012 Jul 1;520(10):2185-201
pubmed: 22237598
Science. 2004 Jul 2;305(5680):96-9
pubmed: 15232109
Nat Commun. 2015 Oct 01;6:8414
pubmed: 26423222
Cell Rep. 2019 May 14;27(7):2014-2021.e2
pubmed: 31091441
Nat Neurosci. 2013 Dec;16(12):1821-9
pubmed: 24141312
Neuron. 2011 Apr 14;70(1):8-19
pubmed: 21482352
Neuropsychologia. 2006;44(13):2636-46
pubmed: 16427666
Curr Biol. 2010 Nov 9;20(21):1938-44
pubmed: 20951043
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7641-6
pubmed: 21502525
Sci Rep. 2014 Nov 19;4:7119
pubmed: 25406576
Nature. 2012 Dec 20;492(7429):433-7
pubmed: 23103875
Nat Neurosci. 2007 May;10(5):623-30
pubmed: 17417635
Nat Neurosci. 2009 Jan;12(1):53-9
pubmed: 19043409
Nat Rev Neurosci. 2012 Jun 20;13(7):478-90
pubmed: 22714019
J Neurosci. 2009 Feb 18;29(7):2225-30
pubmed: 19228975
J Comp Neurol. 2015 Feb 15;523(3):530-44
pubmed: 25327641
Sci Rep. 2015 Aug 10;5:13132
pubmed: 26255707
Semin Cell Dev Biol. 2006 Feb;17(1):20-30
pubmed: 16384719
Sci Rep. 2020 Apr 28;10(1):7153
pubmed: 32346011
Front Physiol. 2020 Feb 11;11:53
pubmed: 32116764
Neuron. 2015 Jun 17;86(6):1478-90
pubmed: 26051421
Curr Biol. 2014 Oct 6;24(19):2247-56
pubmed: 25264257
Nature. 2007 Mar 29;446(7135):542-6
pubmed: 17392786
J Neurosci. 2007 Oct 10;27(41):11132-8
pubmed: 17928455
PLoS Comput Biol. 2010 Aug 05;6(8):
pubmed: 20700495
J Neurosci. 2008 Apr 23;28(17):4368-76
pubmed: 18434515
eNeuro. 2018 Jun 18;5(3):
pubmed: 29938214
PLoS One. 2012;7(6):e38011
pubmed: 22723842
J Neurogenet. 2020 Mar;34(1):92-105
pubmed: 31965876
Nature. 2008 Mar 27;452(7186):473-7
pubmed: 18305480
Cell. 2018 Jul 26;174(3):730-743.e22
pubmed: 30033368
Science. 2020 Jan 3;367(6473):
pubmed: 31896692
Neuron. 1992 Oct;9(4):619-27
pubmed: 1382471
Nat Neurosci. 2016 Dec;19(12):1553-1562
pubmed: 27749830
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13228-31
pubmed: 12235373
Neurosci Biobehav Rev. 2018 May;88:51-62
pubmed: 29540321
Curr Opin Neurobiol. 2013 Feb;23(1):84-91
pubmed: 23084099
Curr Opin Neurobiol. 2007 Oct;17(5):516-24
pubmed: 17950593
Front Neural Circuits. 2009 Jul 01;3:5
pubmed: 19597562
Cell Rep. 2015 Mar 31;10(12):2083-95
pubmed: 25818295
J Neurosci. 2013 Nov 6;33(45):17897-907
pubmed: 24198378
Alcohol Clin Exp Res. 2012 Nov;36(11):1903-12
pubmed: 22551215
J Comp Neurol. 2008 Jun 10;508(5):711-55
pubmed: 18395827
Nature. 2004 Oct 14;431(7010):782-8
pubmed: 15483599
J Neurosci. 2010 May 5;30(18):6461-5
pubmed: 20445072
J Neurosci. 2018 Aug 29;38(35):7701-7712
pubmed: 30030398
Nat Neurosci. 2015 Aug;18(8):1101-8
pubmed: 26098757
J Comp Neurol. 2009 Apr 20;513(6):643-67
pubmed: 19235225
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1482-6
pubmed: 6572401
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13445-52
pubmed: 8942955
Science. 2012 Feb 10;335(6069):678-85
pubmed: 22323813
J Comp Neurol. 2009 Dec 20;517(6):808-24
pubmed: 19844895
Nature. 2013 May 2;497(7447):113-7
pubmed: 23615618
J Comp Neurol. 2002 Apr 8;445(3):211-26
pubmed: 11920702
Nat Neurosci. 2008 Jun;11(6):659-66
pubmed: 18469810
Nat Neurosci. 2007 Nov;10(11):1474-82
pubmed: 17922008
Cell. 2007 Mar 23;128(6):1205-17
pubmed: 17382887
Science. 2017 Apr 7;356(6333):73-78
pubmed: 28386011
Nature. 2017 Mar 30;543(7647):670-675
pubmed: 28329757
Elife. 2015 Nov 17;4:e10719
pubmed: 26573957
J Neurosci. 2013 Jun 5;33(23):9846-54
pubmed: 23739981
Curr Opin Neurobiol. 2018 Apr;49:51-58
pubmed: 29258011
Cell. 1992 Feb 7;68(3):479-89
pubmed: 1739965
Front Behav Neurosci. 2015 Apr 08;9:84
pubmed: 25904854
Bioinformatics. 2009 Aug 1;25(15):1984-6
pubmed: 19376822
J Neurogenet. 2020 Mar;34(1):36-46
pubmed: 32043414