Cystic fibrosis and noninvasive liver fibrosis assessment methods in children.

Child Cystic Fibrosis / complications Elasticity Imaging Techniques / methods Female Humans Liver Cirrhosis / diagnosis Male Reproducibility of Results

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
01 2022
Historique:
received: 28 05 2020
accepted: 08 02 2021
revised: 27 01 2021
pubmed: 19 3 2021
medline: 29 3 2022
entrez: 18 3 2021
Statut: ppublish

Résumé

Noninvasive assessments of liver fibrosis are currently used to evaluate cystic fibrosis (CF)-related liver disease. However, there is scarce data regarding their repeatability and reproducibility, especially in children with CF. The present study aimed to evaluate the repeatability and reproducibility of transient elastography (TE) (FibroScan®) and point shear-wave elastography using virtual touch quantification (pSWE VTQ) in children with CF. TE and pSWE VTQ were performed in 56 children with CF by two different operators. Analysis of repeatability and reproducibility was available in 33 patients for TE and 46 patients for pSWE VTQ. Intra- and interobserver agreement were assessed using the intraclass correlation coefficient (ICC) and their 95% confidence interval (CI), and Bland and Altman graphs. For TE, ICC was 0.91 (0.83-0.95) for intraobserver agreement and 0.92 (95% CI: 0.86-0.96) for interobserver agreement. For pSWE VTQ, ICC was 0.83 (0.72-0.90) for intraobserver agreement and 0.67 (0.48-0.80) for interobserver agreement. Both technics can be proposed in the follow-up of patients, according to their availability in CF centers. This study shows that TE and pSWE VTQ are reliable methods to evaluate liver fibrosis in children with CF. This study shows for the first time that TE and pSWE VTQ are both repeatable and reproducible in children with CF. These data indicate that both TE and pSWE VTQ can be proposed for the follow-up of patients with CF, according to their availability in each CF center.

Sections du résumé

BACKGROUND
Noninvasive assessments of liver fibrosis are currently used to evaluate cystic fibrosis (CF)-related liver disease. However, there is scarce data regarding their repeatability and reproducibility, especially in children with CF. The present study aimed to evaluate the repeatability and reproducibility of transient elastography (TE) (FibroScan®) and point shear-wave elastography using virtual touch quantification (pSWE VTQ) in children with CF.
METHODS
TE and pSWE VTQ were performed in 56 children with CF by two different operators. Analysis of repeatability and reproducibility was available in 33 patients for TE and 46 patients for pSWE VTQ. Intra- and interobserver agreement were assessed using the intraclass correlation coefficient (ICC) and their 95% confidence interval (CI), and Bland and Altman graphs.
RESULTS
For TE, ICC was 0.91 (0.83-0.95) for intraobserver agreement and 0.92 (95% CI: 0.86-0.96) for interobserver agreement. For pSWE VTQ, ICC was 0.83 (0.72-0.90) for intraobserver agreement and 0.67 (0.48-0.80) for interobserver agreement.
CONCLUSIONS
Both technics can be proposed in the follow-up of patients, according to their availability in CF centers.
IMPACT
This study shows that TE and pSWE VTQ are reliable methods to evaluate liver fibrosis in children with CF. This study shows for the first time that TE and pSWE VTQ are both repeatable and reproducible in children with CF. These data indicate that both TE and pSWE VTQ can be proposed for the follow-up of patients with CF, according to their availability in each CF center.

Identifiants

DOI: 10.1038/s41390-021-01427-4 PMID: 33731812
pubmed: 33731812
doi: 10.1038/s41390-021-01427-4
pii: 10.1038/s41390-021-01427-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

223-229

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

Références

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Auteurs

Raphael Enaud (R)

Pediatric Hepatology and Gastroenterology Unit, Bordeaux University Hospital, Pellegrin-Enfants Hospital, Bordeaux, France.
Bordeaux University Hospital, Pellegrin-Enfants Hospital, Pediatric Cystic Fibrosis-Center (CRCM), Bordeaux, France.
INSERM, Centre de Recherche Cardio-thoracique de Bordeaux (U1045), University of Bordeaux, Bordeaux, France.

Eric Frison (E)

Unité de soutien méthodologique à la recherche clinique et épidémiologique, Service d'information médicale, Pôle Santé Publique, Bordeaux University Hospital, Bordeaux, France.
Clinical Investigation Centre (CIC 1401), Bordeaux University Hospital, Bordeaux, France.

Sophie Missonnier (S)

Pediatric Imaging Unit, Bordeaux University Hospital, Pellegrin-Enfants Hospital, Bordeaux, France.

Aude Fischer (A)

Pediatric Hepatology and Gastroenterology Unit, Bordeaux University Hospital, Pellegrin-Enfants Hospital, Bordeaux, France.

Victor de Ledinghen (V)

Hepatology Unit, Bordeaux University Hospital, Haut-Lévêque Hospital, Pessac, France.

Paul Perez (P)

Unité de soutien méthodologique à la recherche clinique et épidémiologique, Service d'information médicale, Pôle Santé Publique, Bordeaux University Hospital, Bordeaux, France.
Clinical Investigation Centre (CIC 1401), Bordeaux University Hospital, Bordeaux, France.

Stéphanie Bui (S)

Bordeaux University Hospital, Pellegrin-Enfants Hospital, Pediatric Cystic Fibrosis-Center (CRCM), Bordeaux, France.

Michael Fayon (M)

Bordeaux University Hospital, Pellegrin-Enfants Hospital, Pediatric Cystic Fibrosis-Center (CRCM), Bordeaux, France.
INSERM, Centre de Recherche Cardio-thoracique de Bordeaux (U1045), University of Bordeaux, Bordeaux, France.
Clinical Investigation Centre (CIC 1401), Bordeaux University Hospital, Bordeaux, France.

Jean-François Chateil (JF)

Pediatric Imaging Unit, Bordeaux University Hospital, Pellegrin-Enfants Hospital, Bordeaux, France.
CRMSB (UMR 5536), University of Bordeaux/CNRS, Bordeaux, France.

Thierry Lamireau (T)

Pediatric Hepatology and Gastroenterology Unit, Bordeaux University Hospital, Pellegrin-Enfants Hospital, Bordeaux, France. thierry.lamireau@chu-bordeaux.fr.
Clinical Investigation Centre (CIC 1401), Bordeaux University Hospital, Bordeaux, France. thierry.lamireau@chu-bordeaux.fr.
ORCID: 0000-0002-5777-8492

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Cystic fibrosis and noninvasive liver fibrosis...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies néonatales › Mucoviscidose › Cystic fibrosis and noninvasive liver fibrosis...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Échographie › Imagerie d'élasticité tissulaire › Cystic fibrosis and noninvasive liver fibrosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cystic fibrosis and noninvasive liver fibrosis...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Cystic fibrosis and noninvasive liver fibrosis...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Cystic fibrosis and noninvasive liver fibrosis...