Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis.
Animals
Axons
/ metabolism
Cells, Cultured
Disease Models, Animal
Disease Susceptibility
Encephalomyelitis, Autoimmune, Experimental
/ diagnosis
Lymphocyte Activation
/ immunology
Magnetic Resonance Imaging
Mice
Mice, Knockout
Microglia
/ immunology
PPAR delta
/ deficiency
Severity of Illness Index
T-Lymphocytes
/ immunology
axon injury
experimental autoimmune encephalomyelitis
microglia
neuroinflammation
peroxisome proliferator-activated receptor
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
06
2020
accepted:
28
01
2021
entrez:
18
3
2021
pubmed:
19
3
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptor (PPAR)-δ is a nuclear receptor that functions to maintain metabolic homeostasis, regulate cell growth, and limit the development of excessive inflammation during immune responses. Previously, we reported that PPAR-δ-deficient mice develop a more severe clinical course of experimental autoimmune encephalomyelitis (EAE); however, it was difficult to delineate the role that microglia played in this disease phenotype since PPAR-δ-deficient mice exhibited a number of immune defects that enhanced CNS inflammation upstream of microglia activation. Here, we specifically investigated the role of PPAR-δ in microglia during EAE by using mice where excision of a floxed
Identifiants
pubmed: 33732230
doi: 10.3389/fimmu.2021.570425
pmc: PMC7959796
doi:
Substances chimiques
PPAR delta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
570425Informations de copyright
Copyright © 2021 Doroshenko, Drohomyrecky, Gower, Whetstone, Cahill, Ganguly, Spring, Yi, Sled and Dunn.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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