Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
Animals
Azacitidine
/ therapeutic use
Chemoradiotherapy
Disease Models, Animal
Drug Synergism
Humans
Immune Checkpoint Inhibitors
/ therapeutic use
Immunotherapy
/ methods
Melanoma
/ immunology
Melanoma, Experimental
Mice
Mice, Inbred C57BL
Receptors, Cell Surface
/ genetics
Signal Transduction
Treatment Outcome
Cancer immunotherapy
Checkpoint inhibitors
Epigenetic therapy
Nucleic acid receptors
RIG-I
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
28
12
2020
received:
28
12
2020
accepted:
04
03
2021
pubmed:
19
3
2021
medline:
25
9
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible RIG-I ligands are small nuclear RNA (snRNA) and endogenous retroviral elements (ERV) leaking from the nucleus during programmed cell death.
Identifiants
pubmed: 33733474
doi: 10.1002/eji.202049158
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Receptors, Cell Surface
0
Robo3 protein, mouse
0
Azacitidine
M801H13NRU
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1531-1534Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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