Risk factor for cerebrospinal fluid leak after endoscopic endonasal skull base surgery: a single-center experience.
Endoscopic endonasal skull base surgery
multiple surgeries
postoperative cerebrospinal fluid leak
Journal
Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
19
3
2021
medline:
30
11
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
One of the major complications in endoscopic endonasal skull base surgery (EESBS) is postoperative cerebrospinal fluid (CSF) leaks. Recently, EESBS has been applied to various skull base diseases as well as more complicated cases influenced by previous treatment with or without various comorbidities. This study aimed to assess the factors that influence the results of postoperative CSF leak after EESBS with mixed patient backgrounds. We conducted a retrospective analysis of the clinical records of patients undergoing EESBS in our institution from 2012 to 2017. Out of a total of 230 cases of EESBS, 11 (4.8%) suffered from postoperative CSF leakage. The rate of CSF leakage for pituitary adenoma, Rathke's cleft cyst, chordoma, and meningioma was 3.5%, 0%, 3.6% and 8.0%, respectively. Multiple variate analysis revealed that repeated surgery ( The rate of postoperative CSF leakage in this study was comparable to previous reports, and repeated surgery may increase postoperative CSF leakage. The surgical strategy for tumor removal as well as skull base reconstruction should be given careful consideration according to tumor pathology and the patient's condition.
Sections du résumé
BACKGROUND
BACKGROUND
One of the major complications in endoscopic endonasal skull base surgery (EESBS) is postoperative cerebrospinal fluid (CSF) leaks. Recently, EESBS has been applied to various skull base diseases as well as more complicated cases influenced by previous treatment with or without various comorbidities.
AIMS/OBJECTIVES
OBJECTIVE
This study aimed to assess the factors that influence the results of postoperative CSF leak after EESBS with mixed patient backgrounds.
MATERIALS AND METHODS
METHODS
We conducted a retrospective analysis of the clinical records of patients undergoing EESBS in our institution from 2012 to 2017.
RESULTS
RESULTS
Out of a total of 230 cases of EESBS, 11 (4.8%) suffered from postoperative CSF leakage. The rate of CSF leakage for pituitary adenoma, Rathke's cleft cyst, chordoma, and meningioma was 3.5%, 0%, 3.6% and 8.0%, respectively. Multiple variate analysis revealed that repeated surgery (
CONCLUSIONS AND SIGNIFICANCE
CONCLUSIONS
The rate of postoperative CSF leakage in this study was comparable to previous reports, and repeated surgery may increase postoperative CSF leakage. The surgical strategy for tumor removal as well as skull base reconstruction should be given careful consideration according to tumor pathology and the patient's condition.
Identifiants
pubmed: 33733997
doi: 10.1080/00016489.2021.1900600
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM