NAD
Animals
Ataxia Telangiectasia
/ diet therapy
Ataxia Telangiectasia Mutated Proteins
/ genetics
Case-Control Studies
Cell Line, Tumor
Dietary Supplements
Disease Models, Animal
Female
Fibroblasts
/ drug effects
Humans
Male
Membrane Proteins
/ genetics
Mice
Mice, Knockout
Mitochondria
/ metabolism
Mitophagy
/ drug effects
NAD
/ metabolism
Neurons
/ drug effects
Niacinamide
/ administration & dosage
Pyridinium Compounds
/ administration & dosage
Rats
Rats, Sprague-Dawley
Senescence-Associated Secretory Phenotype
/ genetics
Signal Transduction
/ drug effects
Transfection
Treatment Outcome
Ataxia Telangiectasia
Nicotinamide riboside
SASP
mitophagy
senescence
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
10
01
2021
received:
18
08
2020
accepted:
04
02
2021
pubmed:
19
3
2021
medline:
26
2
2022
entrez:
18
3
2021
Statut:
ppublish
Résumé
Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in premature aging diseases, including ataxia telangiectasia (A-T). Loss of mitochondrial function can drive age-related decline in the brain, but little is known about whether improving mitochondrial homeostasis alleviates senescence phenotypes. We demonstrate here that mitochondrial dysfunction and cellular senescence with a senescence-associated secretory phenotype (SASP) occur in A-T patient fibroblasts, and in ATM-deficient cells and mice. Senescence is mediated by stimulator of interferon genes (STING) and involves ectopic cytoplasmic DNA. We further show that boosting intracellular NAD
Identifiants
pubmed: 33734555
doi: 10.1111/acel.13329
pmc: PMC8045911
doi:
Substances chimiques
Membrane Proteins
0
Pyridinium Compounds
0
STING1 protein, human
0
Sting1 protein, mouse
0
nicotinamide-beta-riboside
0I8H2M0L7N
NAD
0U46U6E8UK
Niacinamide
25X51I8RD4
ATM protein, human
EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
Atm protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13329Informations de copyright
Published 2021. This article is a U.S. Government work and is in the public domain in the USA. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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