Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell.
Animals
Electrophysiological Phenomena
Female
Interneurons
/ drug effects
Male
Mice
Nerve Net
/ drug effects
Neural Inhibition
Neurons
/ drug effects
Norepinephrine
/ physiology
Nucleus Accumbens
/ physiology
Optogenetics
Parasympathetic Nervous System
/ physiology
Parvalbumins
Patch-Clamp Techniques
Receptors, Adrenergic, alpha-2
/ drug effects
Signal Transduction
/ drug effects
Synaptic Transmission
/ physiology
adrenergic receptor
feedforward inhibition
neorepinephrine
nucleus accumbens
parvalbumin interneurons
prefrontal cortex
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
28 04 2021
28 04 2021
Historique:
received:
15
09
2020
revised:
04
02
2021
accepted:
09
03
2021
pubmed:
20
3
2021
medline:
20
11
2021
entrez:
19
3
2021
Statut:
ppublish
Résumé
The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple midbrain structures. However, little is known how norepinephrine (NE) modulates NAc circuit dynamics. Using a dynamic electrophysiological approach with optogenetics, pharmacology, and drugs acutely restricted by tethering (DART), we explored microcircuit-specific neuromodulatory mechanisms recruited by NE signaling in the NAcSh of parvalbumin (PV)-specific reporter mice. Surprisingly, NE had little direct effect on modulation of synaptic input at medium spiny projection neurons (MSNs). In contrast, we report that NE transmission selectively modulates glutamatergic synapses onto PV-expressing fast-spiking interneurons (PV-INs) by recruiting postsynaptically-localized α
Identifiants
pubmed: 33737458
pii: JNEUROSCI.2420-20.2021
doi: 10.1523/JNEUROSCI.2420-20.2021
pmc: PMC8084318
doi:
Substances chimiques
Parvalbumins
0
Receptors, Adrenergic, alpha-2
0
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3752-3763Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM108554
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH117055
Pays : United States
Organisme : NIMH NIH HHS
ID : DP2 MH119425
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040630
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
Références
Neuropsychopharmacology. 2018 Sep;43(10):2075-2082
pubmed: 29654259
Nature. 1992 Mar 12;356(6365):159-61
pubmed: 1312225
Neuropsychopharmacology. 2016 Jan;41(1):335-56
pubmed: 25976297
ACS Chem Neurosci. 2017 Sep 20;8(9):1913-1924
pubmed: 28594540
J Comp Neurol. 1978 Aug 1;180(3):545-80
pubmed: 659674
Science. 2006 Feb 17;311(5763):1017-20
pubmed: 16484499
Neurosci Lett. 2018 Feb 5;665:117-122
pubmed: 29195907
Neuropsychopharmacology. 2017 Apr;42(5):1146-1156
pubmed: 27929113
Synapse. 1997 Nov;27(3):230-41
pubmed: 9329158
Science. 2017 Apr 7;356(6333):
pubmed: 28385956
Nature. 2000 Jan 27;403(6768):430-4
pubmed: 10667795
Mol Pharmacol. 2016 Apr;89(4):457-66
pubmed: 26843180
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8750-E8759
pubmed: 28973852
J Neurochem. 2007 Mar;100(5):1247-56
pubmed: 17241132
Neuroscience. 2009 Sep 29;163(1):339-51
pubmed: 19527774
J Neurosci. 1996 Mar 1;16(5):1591-604
pubmed: 8774428
J Neurosci. 2018 Oct 17;38(42):9091-9104
pubmed: 30185462
Nature. 2019 May;569(7754):116-120
pubmed: 30944474
Neuron. 2016 Jun 1;90(5):1100-13
pubmed: 27181061
Brain Res. 1998 Sep 28;806(2):127-40
pubmed: 9739125
Learn Mem. 2011 May 20;18(6):405-13
pubmed: 21602321
J Neurosci. 2003 Jun 15;23(12):5272-82
pubmed: 12832552
Mol Neurobiol. 2018 Nov;55(11):8438-8454
pubmed: 29552726
J Neurosci. 2011 May 18;31(20):7402-11
pubmed: 21593324
J Comp Neurol. 1993 Dec 8;338(2):255-78
pubmed: 8308171
Biol Psychiatry. 2021 Mar 15;89(6):588-599
pubmed: 33012522
J Neurosci. 2019 Nov 20;39(47):9277-9293
pubmed: 31578230
Sci Transl Med. 2019 Dec 11;11(522):
pubmed: 31826983
Cell. 2018 Feb 8;172(4):683-695.e15
pubmed: 29425490
Neuroscience. 2018 Feb 10;371:126-137
pubmed: 29229557
J Neurophysiol. 1998 Apr;79(4):1768-76
pubmed: 9535946
Neuropsychopharmacology. 2010 Nov;35(12):2346-56
pubmed: 20686455
J Neurosci. 1993 Nov;13(11):4908-23
pubmed: 7693897
Neuropsychopharmacology. 2018 Apr;43(5):953-963
pubmed: 28840858
Cell Rep. 2015 Sep 29;12(12):1997-2008
pubmed: 26365195
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8570-8575
pubmed: 30971490
J Neurosci. 2002 Jul 15;22(14):5817-22
pubmed: 12122043
Neuron. 2011 Feb 24;69(4):650-63
pubmed: 21338877
Am J Physiol. 1997 Dec;273(6):R2080-8
pubmed: 9435664
Eur J Neurosci. 2009 Apr;29(8):1579-87
pubmed: 19385993
Cell Rep. 2020 Jul 28;32(4):107971
pubmed: 32726634
Biol Psychiatry. 2019 Dec 1;86(11):836-847
pubmed: 31471038
J Neurosci. 2018 Oct 17;38(42):8922-8942
pubmed: 30150361
Neuropharmacology. 2018 Mar 15;131:154-165
pubmed: 29225042
Neurochem Res. 1988 Oct;13(10):937-42
pubmed: 3216951
Elife. 2019 Oct 09;8:
pubmed: 31596232
Neuropsychopharmacology. 2012 Aug;37(9):2161-72
pubmed: 22588352
Cell Rep. 2018 Jun 26;23(13):3852-3863
pubmed: 29949769