Brain activation patterns in medicated versus medication-naïve adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching.
Adult
Attention
/ drug effects
Attention Deficit Disorder with Hyperactivity
/ diagnostic imaging
Brain
/ diagnostic imaging
Case-Control Studies
Cognition
/ drug effects
Corpus Striatum
/ diagnostic imaging
Diagnosis, Differential
Frontal Lobe
/ diagnostic imaging
Humans
Intelligence
/ drug effects
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Neuropsychological Tests
Parietal Lobe
/ diagnostic imaging
Psychomotor Performance
/ drug effects
Reaction Time
Visual Perception
/ drug effects
Young Adult
ADHD
Adults
Diagnosis
Functional MRI
Neuroimaging
Journal
BMC medical imaging
ISSN: 1471-2342
Titre abrégé: BMC Med Imaging
Pays: England
ID NLM: 100968553
Informations de publication
Date de publication:
19 03 2021
19 03 2021
Historique:
received:
26
10
2020
accepted:
04
03
2021
entrez:
20
3
2021
pubmed:
21
3
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Adult-attention-deficit-hyperactive-disorder (ADHD) is often unrecognized condition. FMRI examination along with neuropsychological testing might strengthen the diagnosis. We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while testing tasks of motor inhibition and cognitive switching. 45 subjects in three age-matched groups: (1) controls, (2) ADHD-adults under medication (ADHD+) and (3) medication-naïve adults with ADHD (ADHD-) underwent fMRI and neuropsychological testing. Group analysis and population-based statistics were performed. DTVP-A, intellectual ability as well as attention capability, visual-perceptual and visual-motor abilities showed no significant differences between the groups. However, fMRI revealed statistically significant differences between the ADHD+, ADHD- and control groups on tasks of motor inhibition and cognitive switching on adults in bilateral fronto-striatal brain regions, inferior fronto-frontal, fronto-cingulate and fronto-parietal networks as well as in the parietal lobe (p < 0.05). fMRI offers the potential to differentiate between the ADHD+, ADHD- and control groups. FMRI possibly opens a new window for monitoring the therapeutic effect of ADHD medication. NCT02578342, registered at August 2015 to clinical trial registry ( https://ichgcp.net/clinical-trials-registry/NCT02578342 ).
Sections du résumé
BACKGROUND
Adult-attention-deficit-hyperactive-disorder (ADHD) is often unrecognized condition. FMRI examination along with neuropsychological testing might strengthen the diagnosis. We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while testing tasks of motor inhibition and cognitive switching.
METHODS
45 subjects in three age-matched groups: (1) controls, (2) ADHD-adults under medication (ADHD+) and (3) medication-naïve adults with ADHD (ADHD-) underwent fMRI and neuropsychological testing. Group analysis and population-based statistics were performed.
RESULTS
DTVP-A, intellectual ability as well as attention capability, visual-perceptual and visual-motor abilities showed no significant differences between the groups. However, fMRI revealed statistically significant differences between the ADHD+, ADHD- and control groups on tasks of motor inhibition and cognitive switching on adults in bilateral fronto-striatal brain regions, inferior fronto-frontal, fronto-cingulate and fronto-parietal networks as well as in the parietal lobe (p < 0.05).
CONCLUSIONS
fMRI offers the potential to differentiate between the ADHD+, ADHD- and control groups. FMRI possibly opens a new window for monitoring the therapeutic effect of ADHD medication.
TRIAL REGISTRATION
NCT02578342, registered at August 2015 to clinical trial registry ( https://ichgcp.net/clinical-trials-registry/NCT02578342 ).
Identifiants
pubmed: 33740903
doi: 10.1186/s12880-021-00579-3
pii: 10.1186/s12880-021-00579-3
pmc: PMC7977301
doi:
Banques de données
ClinicalTrials.gov
['NCT02578342']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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