ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.

Animals DNA-Binding Proteins / genetics Disease Models, Animal Ependymoma / genetics Mice Supratentorial Neoplasms / genetics Transcription Factor RelA / genetics Transcription Factors / genetics

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
09 2021
Historique:
received: 22 07 2020
revised: 05 01 2021
accepted: 16 03 2021
pubmed: 21 3 2021
medline: 1 4 2022
entrez: 20 3 2021
Statut: ppublish

Résumé

More than 60% of supratentorial ependymomas harbor a

Identifiants

DOI: 10.1158/2159-8290.CD-20-1066 PMID: 33741710 PMC: PMC8418998
pubmed: 33741710
pii: 2159-8290.CD-20-1066
doi: 10.1158/2159-8290.CD-20-1066
pmc: PMC8418998
mid: NIHMS1687782
doi:

Substances chimiques

2700081O15Rik protein, mouse 0
DNA-Binding Proteins 0
RELA protein, human 0
Transcription Factor RelA 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2200-2215

Subventions

Organisme : NCI NIH HHS
ID : R01 CA223388
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217842
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM056929
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA090433
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM069234
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA187565
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS116361
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM137996
Pays : United States

Informations de copyright

©2021 American Association for Cancer Research.

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Auteurs

Amir Arabzade (A)

Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas.
Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.

Yanhua Zhao (Y)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.

Srinidhi Varadharajan (S)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
ORCID: 0000-0002-2033-0758

Hsiao-Chi Chen (HC)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Cancer and Cell Biology Program, Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, Texas.
ORCID: 0000-0002-7505-6119

Selin Jessa (S)

Quantitative Life Sciences, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0003-4192-6523

Bryan Rivas (B)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.

Austin J Stuckert (AJ)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
ORCID: 0000-0002-5938-7495

Minerva Solis (M)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Cancer and Cell Biology Program, Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, Texas.

Alisha Kardian (A)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Cancer and Cell Biology Program, Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, Texas.

Dana Tlais (D)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
ORCID: 0000-0002-0060-8070

Brian J Golbourn (BJ)

Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Ann-Catherine J Stanton (AJ)

Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Yuen San Chan (YS)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Department of Molecular and Cellular Biology and Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas.
Department of Bioengineering, Rice University, Houston, Texas.
Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Calla Olson (C)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
Department of Biochemistry and Molecular Biology, Houston, Texas.

Kristen L Karlin (KL)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
Department of Biochemistry and Molecular Biology, Houston, Texas.

Kathleen Kong (K)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.

Robert Kupp (R)

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England.
Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, England.

Baoli Hu (B)

Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
ORCID: 0000-0002-2737-6871

Sarah G Injac (SG)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
ORCID: 0000-0002-6389-369X

Madeline Ngo (M)

Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas.
ORCID: 0000-0003-3610-6475

Peter R Wang (PR)

Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas.

Luz A De León (LA)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.

Felix Sahm (F)

Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
ORCID: 0000-0001-5441-1962

Daisuke Kawauchi (D)

Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Biochemistry and Cellular Biology, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
ORCID: 0000-0002-1254-9725

Stefan M Pfister (SM)

Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Department of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
ORCID: 0000-0002-5447-5322

Charles Y Lin (CY)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

H Courtney Hodges (HC)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Department of Molecular and Cellular Biology and Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas.
Department of Bioengineering, Rice University, Houston, Texas.
Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
ORCID: 0000-0003-4441-497X

Irtisha Singh (I)

Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.

Thomas F Westbrook (TF)

Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
Department of Biochemistry and Molecular Biology, Houston, Texas.

Murali M Chintagumpala (MM)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.

Susan M Blaney (SM)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.

Donald W Parsons (DW)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.

Kristian W Pajtler (KW)

Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Department of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.

Sameer Agnihotri (S)

Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Richard J Gilbertson (RJ)

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England.
Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, England.
ORCID: 0000-0001-7539-9472

Joanna Yi (J)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.

Nada Jabado (N)

Quantitative Life Sciences, McGill University, Montreal, Quebec, Canada.
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

Claudia L Kleinman (CL)

Quantitative Life Sciences, McGill University, Montreal, Quebec, Canada.
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Lady Davis Research Institute, Jewish General Hospital, Quebec, Canada.
ORCID: 0000-0002-5158-7126

Kelsey C Bertrand (KC)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas. stephen.mack@stjude.org deneen@bcm.edu stephen.mack@stjude.org.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.

Benjamin Deneen (B)

Cancer and Cell Biology Program, Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, Texas. stephen.mack@stjude.org deneen@bcm.edu stephen.mack@stjude.org.
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas.
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

Stephen C Mack (SC)

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, Texas. stephen.mack@stjude.org deneen@bcm.edu stephen.mack@stjude.org.
Therapeutic Innovation Center at Baylor College of Medicine, Houston, Texas.
Cancer and Cell Biology Program, Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, Texas.
ORCID: 0000-0001-9620-4742

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Épendymome › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Tumeurs sus-tentorielles › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Facteur de transcription RelA › ZFTA-RELA Dictates Oncogenic Transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › ZFTA-RELA Dictates Oncogenic Transcriptional...