Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance.
Anemia, Sickle Cell
/ metabolism
Erythrocyte Membrane
/ metabolism
Erythrocytes
/ metabolism
Flow Cytometry
/ methods
Hemolysis
Humans
Ligands
Malaria, Falciparum
/ metabolism
Mannose
/ metabolism
Membrane Glycoproteins
/ metabolism
Phagocytes
/ metabolism
Phagocytosis
Plasmodium falciparum
/ physiology
Polysaccharides
/ metabolism
Protein Binding
Receptors, Immunologic
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 03 2021
19 03 2021
Historique:
received:
18
02
2019
accepted:
08
02
2021
entrez:
20
3
2021
pubmed:
21
3
2021
medline:
7
4
2021
Statut:
epublish
Résumé
In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man
Identifiants
pubmed: 33741926
doi: 10.1038/s41467-021-21814-z
pii: 10.1038/s41467-021-21814-z
pmc: PMC7979802
doi:
Substances chimiques
Ligands
0
MRC1 protein, human
0
Membrane Glycoproteins
0
Polysaccharides
0
Receptors, Immunologic
0
Mannose
PHA4727WTP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1792Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F008309/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 082098
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBF0083091
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102705
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 094847
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N006364/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBK0161641
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 97377
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102705/Z/13/Z
Pays : United Kingdom
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