Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.

Antibodies, Viral / blood Antiviral Agents / pharmacology COVID-19 / blood Caco-2 Cells Humans Immunoglobulin G / blood Molecular Docking Simulation SARS-CoV-2 / drug effects Serine Endopeptidases / metabolism Serine Proteinase Inhibitors / pharmacology Spike Glycoprotein, Coronavirus / metabolism Virus Internalization / drug effects Virus Replication / drug effects alpha 1-Antitrypsin / pharmacology COVID-19 Drug Treatment

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
19 03 2021

Historique:

received: 16 07 2020

accepted: 18 02 2021

entrez: 20 3 2021

pubmed: 21 3 2021

medline: 10 4 2021

Statut: epublish

Résumé

SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our knowledge about innate immune factors of the respiratory tract against SARS-CoV-2 is limited, we generated and screened a peptide/protein library derived from bronchoalveolar lavage for inhibitors of SARS-CoV-2 spike-driven entry. Analysis of antiviral fractions revealed the presence of α

Identifiants

DOI: 10.1038/s41467-021-21972-0 PMID: 33741941 PMC: PMC7979852

pubmed: 33741941

doi: 10.1038/s41467-021-21972-0

pii: 10.1038/s41467-021-21972-0

pmc: PMC7979852

doi:

Substances chimiques

Antibodies, Viral 0

Antiviral Agents 0

Immunoglobulin G 0

Serine Proteinase Inhibitors 0

Spike Glycoprotein, Coronavirus 0

alpha 1-Antitrypsin 0

spike protein, SARS-CoV-2 0

Serine Endopeptidases EC 3.4.21.-

TMPRSS2 protein, human EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1726

Références

Rev Med Virol. 2021 Mar;31(2):e2157

pubmed: 32844538

J Virol. 2006 Oct;80(19):9896-8

pubmed: 16973594

J Virol. 2013 Jun;87(11):6150-60

pubmed: 23536651

Am Rev Respir Dis. 1987 Mar;135(3):539-43

pubmed: 3493719

J Biol Chem. 2003 Sep 26;278(39):37881-7

pubmed: 12860985

Clin Microbiol Rev. 2011 Jan;24(1):210-29

pubmed: 21233513

N Engl J Med. 2020 Dec 31;383(27):2684-2686

pubmed: 33326716

Nature. 1982 Jul 22;298(5872):329-34

pubmed: 7045697

Nat Med. 2020 Jul;26(7):1017-1032

pubmed: 32651579

EBioMedicine. 2020 Aug;58:102925

pubmed: 32745993

Cell. 2020 Apr 16;181(2):271-280.e8

pubmed: 32142651

PLoS One. 2011;6(10):e25858

pubmed: 21998709

J Inherit Metab Dis. 2008 Feb;31(1):21-34

pubmed: 18193338

Respir Res. 2006 Feb 17;7:29

pubmed: 16503962

Am J Med. 1988 Jun 24;84(6A):52-62

pubmed: 3289387

J Clin Invest. 1990 May;85(5):1343-52

pubmed: 2185272

Am J Respir Crit Care Med. 2019 Aug 1;200(3):318-326

pubmed: 30965011

J Virol. 2019 Oct 15;93(21):

pubmed: 31391268

Nat Rev Microbiol. 2014 Oct;12(10):715-22

pubmed: 25110191

J Clin Invest. 1981 Nov;68(5):1158-65

pubmed: 7028785

J Chem Theory Comput. 2020 Mar 10;16(3):1396-1410

pubmed: 32109052

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):453-8

pubmed: 9012804

Cell. 2020 Aug 20;182(4):812-827.e19

pubmed: 32697968

J Virol. 2012 Jun;86(12):6537-45

pubmed: 22496216

Cancer Discov. 2014 Nov;4(11):1310-25

pubmed: 25122198

Front Microbiol. 2020 Apr 06;11:508

pubmed: 32328038

Annu Rev Biochem. 1983;52:655-709

pubmed: 6193754

JAMA. 1988 Sep 2;260(9):1259-64

pubmed: 3261353

Cell Rep Med. 2020 Jul 21;1(4):100059

pubmed: 32835306

Cell. 2020 Jul 23;182(2):429-446.e14

pubmed: 32526206

Biochem J. 2005 Jun 15;388(Pt 3):967-72

pubmed: 15537383

J Virol. 2010 Dec;84(24):12658-64

pubmed: 20926566

Elife. 2020 Apr 02;9:

pubmed: 32228860

Sci Adv. 2019 Apr 10;5(4):eaav4580

pubmed: 30989115

Cancer Res. 2015 Jul 15;75(14):2949-60

pubmed: 26018085

Antimicrob Agents Chemother. 2013 Oct;57(10):4751-60

pubmed: 23856778

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S280-8

pubmed: 27564662

Cell Mol Gastroenterol Hepatol. 2021;11(4):935-948

pubmed: 33186749

Cell. 2007 Apr 20;129(2):263-75

pubmed: 17448989

Med Hypotheses. 2021 Jan;146:110394

pubmed: 33239231

Nat Genet. 2008 Jul;40(7):871-9

pubmed: 18552847

Am J Respir Crit Care Med. 2020 Sep 15;202(6):812-821

pubmed: 32584597

PLoS Pathog. 2013;9(12):e1003774

pubmed: 24348248

Nat Rev Immunol. 2020 Jun;20(6):363-374

pubmed: 32346093

J Clin Invest. 1989 Oct;84(4):1349-54

pubmed: 2794066

J Exp Med. 2020 Jun 1;217(6):

pubmed: 32302401

COPD. 2013 Dec;10(6):687-95

pubmed: 23862647

J Virol. 2013 May;87(10):5502-11

pubmed: 23468491

Sci Transl Med. 2010 Dec 22;2(63):63re3

pubmed: 21178138