Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
13
07
2020
accepted:
01
03
2021
revised:
14
02
2021
pubmed:
21
3
2021
medline:
19
3
2022
entrez:
20
3
2021
Statut:
ppublish
Résumé
Fatty acid synthase (FASN) is the only human lipogenic enzyme available for de novo fatty acid synthesis and is often highly expressed in cancer cells. We found that FASN mRNA levels were significantly higher in acute myeloid leukemia (AML) patients than in healthy granulocytes or CD34
Identifiants
pubmed: 33742137
doi: 10.1038/s41418-021-00768-1
pii: 10.1038/s41418-021-00768-1
pmc: PMC8329134
doi:
Substances chimiques
FASN protein, human
EC 2.3.1.85
Fatty Acid Synthase, Type I
EC 2.3.1.85
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2465-2481Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
ID : 31003A_173219
Organisme : UniBern Forschungsstiftung (Bern University Research Foundation)
ID : 45/2018
Informations de copyright
© 2021. The Author(s).
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