Abnormalities in Tooth Formation after Early Bisphosphonate Treatment in Children with Osteogenesis Imperfecta.
Bisphosphonates
Enamel
Osteogenesis imperfecta
Tooth abnormalities
Tooth agenesis
Tooth morphology
Journal
Calcified tissue international
ISSN: 1432-0827
Titre abrégé: Calcif Tissue Int
Pays: United States
ID NLM: 7905481
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
19
01
2021
accepted:
03
03
2021
pubmed:
21
3
2021
medline:
16
10
2021
entrez:
20
3
2021
Statut:
ppublish
Résumé
Treatment with intravenous bisphosphonate (BP) in children and adolescents with osteogenesis imperfecta (OI) started in Sweden in 1991. No human studies on the role of BP therapy in development of disturbances in tooth mineralization or tooth morphology have been published. The study cohort comprised 219 individuals who were divided into four groups: group 1, BP treatment onset before 2 years of age (n = 22); group 2, BP treatment onset between 2 and 6 years of age (n = 20); group 3, BP treatment onset between 6 and 10 years of age (n = 13); and a control group of patients with OI who had not received BP therapy (n = 164). The chi-square test was used in between-group comparisons of the prevalence of tooth agenesis. The prevalence of tooth agenesis was significantly higher in children who began BP treatment before the age of 2 years (group 1; 59%,) compared to the controls (10%; p < 0.001) and to children who had begun BP therapy between ages 2 and 6 years (group 2; 10%; p = 0.009) or between ages 6 and 10 years (group 3; 8%; p = 0.003). Different types of disturbances in the enamel formation were seen in 52 premolars, where 51 were seen in those who began BP treatment before the age of 2 years. To conclude, starting BP treatment before the age of 2 years increases the risk of abnormalities in tooth formation manifesting as morphological aberrations, tooth agenesis, and enamel defects.
Identifiants
pubmed: 33743023
doi: 10.1007/s00223-021-00835-2
pii: 10.1007/s00223-021-00835-2
pmc: PMC8273054
doi:
Substances chimiques
Diphosphonates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
121-131Subventions
Organisme : Stiftelsen Olle Engkvist Byggmästare
ID : 191-449
Organisme : Stiftelsen Sunnerdahls Handikappfond
ID : 35/18
Organisme : Stiftelsen Sunnerdahls Handikappfond
ID : 40/19
Informations de copyright
© 2021. The Author(s).
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