Early life stress induces a transient increase in hippocampal corticotropin-releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides.
Animals
Rats
Corticosterone
/ metabolism
Corticotropin-Releasing Hormone
/ metabolism
Hippocampus
/ metabolism
Hypothalamo-Hypophyseal System
/ metabolism
Hypothalamus
/ metabolism
Maternal Deprivation
Neuropeptides
/ metabolism
Pituitary-Adrenal System
/ metabolism
Stress, Psychological
/ metabolism
corticosterone
corticotropin-releasing hormone
hippocampus
maternal separation
vasopressin
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
30
10
2020
accepted:
10
03
2021
pubmed:
22
3
2021
medline:
1
6
2022
entrez:
21
3
2021
Statut:
ppublish
Résumé
Early life stress (ELS) programs hypothalamus-pituitary-adrenal (HPA) axis activity and affects synaptic plasticity and cognitive performance in adults; however, the effects of ELS during the temporal window of vulnerability are poorly understood. This study aimed to thoroughly characterize the effects of ELS in the form of periodic maternal separation (MS180) during the time of exposure to stress. Hippocampal corticotropin-releasing hormone (CRH) gene expression and baseline HPA axis activity were analyzed at postnatal (P) days 6, 12, 15, and 21, and in adulthood (P75); these factors were correlated with plasticity markers and adult behavior. Our results indicate that MS180 induces an increase in hippocampal CRH expression at P9, P12, and P15, whereas an increase in hypothalamic CRH expression was observed from P12 to P21. Increased arginine-vasopressin expression and corticosterone levels were observed only at P21. Moreover, MS180 caused transient alterations in hypothalamic synaptophysin expression during early life. As adults, MS180 rats showed a passive coping strategy in the forced swimming test, cognitive impairments in the object location test, increased hypothalamic CRH expression, and decreased oxytocin (OXT) expression. Spearman's analysis indicated that cognitive impairments correlated with CRH and OXT expression. In conclusion, our data indicate that MS180 induces a transient increase in hippocampal CRH expression in neonates that precedes the effects on hypothalamic neuropeptides, confirming the role of increased CRH during the temporal window of vulnerability as a mediator of some of the detrimental effects of ELS on brain development and adult behavior.
Substances chimiques
Corticosterone
W980KJ009P
Corticotropin-Releasing Hormone
9015-71-8
Neuropeptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2108-2121Informations de copyright
© 2021 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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