Role of the HLA-G immune checkpoint molecule in pregnancy.
HLA-G
Isoform
Polymorphism
Signaling
Trogocytosis
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
30
10
2020
revised:
22
12
2020
accepted:
05
01
2021
pubmed:
23
3
2021
medline:
4
1
2022
entrez:
22
3
2021
Statut:
ppublish
Résumé
The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of trophoblast invasion, uterine vascular remodeling, and maintenance of a local immunosuppressive state. Understanding HLA-G biology at the maternal-fetal interface is therefore a critical issue in reproduction. In this regard, we review here: (i) the effects of HLA-G on decidual leucocytes and stromal cells, (ii) the contribution of trogocytosis in HLA-G expression on decidual cells, (iii) its interaction with the ILT2, ILT4 and KIR2DL4 receptors, (iv) the link between HLA-G polymorphism and pregnancy disorders, and (v) the expression of newly-described HLA-G isoforms at the maternal-fetal interface.
Identifiants
pubmed: 33745758
pii: S0198-8859(21)00010-0
doi: 10.1016/j.humimm.2021.01.003
pii:
doi:
Substances chimiques
HLA-G Antigens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-361Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.