GPR55 in the brain and chronic neuropathic pain.
Animals
Benzimidazoles
/ pharmacology
Cannabinoid Receptor Antagonists
/ administration & dosage
Chronic Pain
/ drug therapy
Disease Models, Animal
Male
Neuralgia
/ drug therapy
Periaqueductal Gray
/ drug effects
Rats
Rats, Sprague-Dawley
Receptors, Cannabinoid
/ metabolism
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
GPR55
PAG
Pain
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
21 05 2021
21 05 2021
Historique:
received:
22
04
2020
revised:
26
02
2021
accepted:
12
03
2021
pubmed:
23
3
2021
medline:
27
1
2022
entrez:
22
3
2021
Statut:
ppublish
Résumé
There is a clear need for novel and improved therapeutic strategies for alleviating chronic neuropathic pain, as well as a need for better understanding of brain mechanisms of neuropathic pain, which are less understood than spinal and peripheral mechanisms. The G protein-coupled receptor 55 (GPR55), is a lysophosphatidylinositol (LPI)-sensitive receptor that has also been involved in cannabinoid signaling. It is expressed throughout the central nervous system, including the periaqueductal gray (PAG), a brainstem area and key element of the descending pain control system. Behaviors, pharmacology, biochemistry tools, and stereotaxic microinjections were used to determine if GPR55 plays a role in pain control in a chronic constriction injury (CCI) neuropathic pain model in rats. It was found that the blockade of GPR55 action in the PAG can restore and drive a descending control system to mitigate neuropathic pain. Our data demonstrate that GPR55 play a role in the descending pain control system, and identify GPR55 at supraspinal level as a neuropathic pain brain mechanism.
Identifiants
pubmed: 33745983
pii: S0166-4328(21)00136-4
doi: 10.1016/j.bbr.2021.113248
pii:
doi:
Substances chimiques
1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-((3-hydroxypropyl)amino)-5,6-dimethyl-1H-benzo(d)imidazol-1-yl)ethanone
0
Benzimidazoles
0
Cannabinoid Receptor Antagonists
0
GPR55 protein, rat
0
Receptors, Cannabinoid
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113248Subventions
Organisme : NIDA NIH HHS
ID : R01 DA035926
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.