Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique.
Adult
Antibodies
/ immunology
Antigens
/ immunology
Antiretroviral Therapy, Highly Active
Female
Fetal Blood
/ immunology
HIV Infections
/ drug therapy
Humans
Immunity, Maternally-Acquired
Immunoglobulin G
/ immunology
Maternal-Fetal Exchange
/ immunology
Mozambique
Placenta
/ immunology
Pregnancy
Protein Transport
Sex Factors
Vaccines
/ immunology
Young Adult
HIV
IgG
IgG subclasses
antibody
malaria
maternal antibodies
pathogens
placental transfer
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
10
2020
accepted:
08
02
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
30
6
2021
Statut:
epublish
Résumé
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of IgG subclasses. We measured total IgG and IgG subclasses by quantitative suspension array technology against 14 pathogens and vaccine antigens, including targets of maternal immunization, in 341 delivering HIV-uninfected and HIV-infected mother-infant pairs from southern Mozambique. We analyzed the association of maternal HIV infection,
Identifiants
pubmed: 33746958
doi: 10.3389/fimmu.2021.614246
pmc: PMC7965965
doi:
Substances chimiques
Antibodies
0
Antigens
0
Immunoglobulin G
0
Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
614246Informations de copyright
Copyright © 2021 Alonso, Vidal, Ruiz-Olalla, González, Manaca, Jairoce, Vázquez-Santiago, Balcells, Vala, Rupérez, Cisteró, Fuente-Soro, Cova, Angov, Nhacolo, Sevene, Aponte, Macete, Aguilar, Mayor, Menéndez, Dobaño and Moncunill.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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