Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.

Caco-2 Cells Ethanol Flavonoids Humans Intestinal Mucosa Luteolin / pharmacology Mitogen-Activated Protein Kinase Kinases NF-E2-Related Factor 2 / genetics NF-kappa B / genetics Tight Junctions
ethanol flavonoids intestinal barrier luteolin oxidative stress

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
14 Apr 2021
Historique:
pubmed: 23 3 2021
medline: 15 5 2021
entrez: 22 3 2021
Statut: ppublish

Résumé

Luteolin, a dietary flavonoid, has gained increasing interest as an intestinal protectant. This study aimed to evaluate the reparative effect of luteolin against ethanol-induced intestinal barrier damage in a Caco-2 cell monolayer model and the potential mechanisms. Luteolin attenuated ethanol-induced intestinal barrier injury, by increasing transepithelial monolayer resistance (TEER, 27.75 ± 14.75% of the ethanol group,

Identifiants

DOI: 10.1021/acs.jafc.1c00199 PMID: 33749262
pubmed: 33749262
doi: 10.1021/acs.jafc.1c00199
doi:

Substances chimiques

Flavonoids 0
NF-E2-Related Factor 2 0
NF-kappa B 0
Ethanol 3K9958V90M
Mitogen-Activated Protein Kinase Kinases EC 2.7.12.2
Luteolin KUX1ZNC9J2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4101-4110

Auteurs

Jinwen Yuan (J)

State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.

Siyan Che (S)

State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.

Li Zhang (L)

State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.

Zheng Ruan (Z)

State Key Laboratory of Food Science and Technology, Nanchang Key Laboratory of Fruits and Vegetables Nutrition and Processing, Institute of Nutrition and School of Food Science, Nanchang University, Nanchang 330047, China.
ORCID: 0000-0001-9638-1466

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavones › Lutéoline › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Mitogen-Activated Protein Kinase Kinases › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Reparative Effects of Ethanol-Induced...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions serrées › Reparative Effects of Ethanol-Induced...