Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area.
COVID-19
Genetic variation
Journal
JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073
Informations de publication
Date de publication:
22 03 2021
22 03 2021
Historique:
received:
28
09
2020
accepted:
10
02
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
7
4
2021
Statut:
epublish
Résumé
The early COVID-19 pandemic was characterized by rapid global spread. In Maryland and Washington, DC, United States, more than 2500 cases were reported within 3 weeks of the first COVID-19 detection in March 2020. We aimed to use genomic sequencing to understand the initial spread of SARS-CoV-2 - the virus that causes COVID-19 - in the region. We analyzed 620 samples collected from the Johns Hopkins Health System during March 11-31, 2020, comprising 28.6% of the total cases in Maryland and Washington, DC. From these samples, we generated 114 complete viral genomes. Analysis of these genomes alongside a subsampling of over 1000 previously published sequences showed that the diversity in this region rivaled global SARS-CoV-2 genetic diversity at that time and that the sequences belong to all of the major globally circulating lineages, suggesting multiple introductions into the region. We also analyzed these regional SARS-CoV-2 genomes alongside detailed clinical metadata and found that clinically severe cases had viral genomes belonging to all major viral lineages. We conclude that efforts to control local spread of the virus were likely confounded by the number of introductions into the region early in the epidemic and the interconnectedness of the region as a whole.
Identifiants
pubmed: 33749660
pii: 144350
doi: 10.1172/jci.insight.144350
pmc: PMC8026189
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400007C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134384
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010538
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG006620
Pays : United States
Commentaires et corrections
Type : UpdateOf
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