Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning.
Animals
Casein Kinase I
/ metabolism
Connexin 43
/ genetics
Disease Models, Animal
Ischemic Preconditioning, Myocardial
Isolated Heart Preparation
Mice, Mutant Strains
Mitochondria, Heart
/ enzymology
Myocardial Infarction
/ enzymology
Myocardial Reperfusion Injury
/ enzymology
Myocytes, Cardiac
/ enzymology
Phosphorylation
Connexin
Hemichannel
Ischemia/reperfusion
Ischemic preconditioning
Mitochondria
Phosphorylation
Journal
Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342
Informations de publication
Date de publication:
22 03 2021
22 03 2021
Historique:
received:
28
09
2020
accepted:
10
03
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Myocardial connexin 43 (Cx43) forms gap junctions and hemichannels, and is also present within subsarcolemmal mitochondria. The protein is phosphorylated by several kinases including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and casein kinase 1 (CK1). A reduction in Cx43 content abrogates myocardial infarct size reduction by ischemic preconditioning (IPC). The present study characterizes the contribution of Cx43 phosphorylation towards mitochondrial function, hemichannel activity, and the cardioprotection by IPC in wild-type (WT) mice and in mice in which Cx43-phosphorylation sites targeted by above kinases are mutated to non-phosphorylatable residues (Cx43
Identifiants
pubmed: 33751227
doi: 10.1007/s00395-021-00861-z
pii: 10.1007/s00395-021-00861-z
pmc: PMC7985055
doi:
Substances chimiques
Connexin 43
0
GJA1 protein, mouse
0
Casein Kinase I
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM055632
Pays : United States
Organisme : US National Institutes of Health
ID : PDL-GM55632
Organisme : German Research Foundation
ID : BO 2955/4-1
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