The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders.
LncRNA
MiRNA
NF-κB
Nuclear factor-κB
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
17
01
2021
revised:
27
02
2021
accepted:
14
03
2021
pubmed:
24
3
2021
medline:
24
7
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
Nuclear factor-κB (NF-κB) represents a group of inducible transcription factors (TFs) regulating the expression of a great variety of genes implicated in diverse processes, particularly modulation of immune system responses. This TF has functional interactions with non-coding RNAs, constructing a complicated network through which NF-κB, miRNAs, and lncRNAs coordinately regulate gene expression at different facets. This type of interaction is involved in the pathophysiology of several human disorders including both neoplastic disorders and non-neoplastic conditions. MALAT1 and NKILA are among lncRNAs whose interactions with NF-κB have been vastly assessed in different conditions including cancer and inflammatory conditions. In addition, miR-146a/b has functional interactions with this TF in different contexts. Although miRNAs have mutual interactions with NF-κB, the regulatory role of miRNAs on this TF has been more clarified. The aim of the current review is to explore the function of NF-κB-related miRNAs and lncRNAs in these two types of human disorders.
Identifiants
pubmed: 33756159
pii: S0753-3322(21)00304-8
doi: 10.1016/j.biopha.2021.111519
pii:
doi:
Substances chimiques
Inflammation Mediators
0
MicroRNAs
0
NF-kappa B
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111519Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.