Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 03 2021
23 03 2021
Historique:
received:
23
01
2020
accepted:
22
02
2021
entrez:
24
3
2021
pubmed:
25
3
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Cardiac development is a dynamic process, temporally and spatially. When disturbed, it leads to congenital cardiac anomalies that affect approximately 1% of live births. Genetic variants in several loci lead to anomalies, with the transcription factor NKX2-5 being one of the largest. However, there are also non-genetic factors that influence cardiac malformations. We examined the hypothesis that hyperoxia may be beneficial and can rescue genetic cardiac anomalies induced by an Nkx2-5 mutation. Intermittent mild hyperoxia (40% PO
Identifiants
pubmed: 33758249
doi: 10.1038/s41598-021-85569-9
pii: 10.1038/s41598-021-85569-9
pmc: PMC7988122
doi:
Substances chimiques
Homeobox Protein Nkx-2.5
0
Nkx2-5 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6608Subventions
Organisme : NICHD NIH HHS
ID : R21 HD090608
Pays : United States
Références
J Clin Invest. 1999 Dec;104(11):1567-73
pubmed: 10587520
Mol Cell Biol. 1996 Sep;16(9):4604-13
pubmed: 8756616
Nucleic Acids Res. 2013 Sep;41(17):7997-8010
pubmed: 23851566
Cell Rep. 2015 Oct 27;13(4):723-732
pubmed: 26489465
Can J Cardiol. 2017 Jun;33(6):747-757
pubmed: 28395867
Biochem J. 1997 Oct 15;327 ( Pt 2):419-23
pubmed: 9359410
Sci Rep. 2016 Dec 16;6:39304
pubmed: 27982102
Ultrasound Obstet Gynecol. 2016 Sep;48(3):365-72
pubmed: 26700848
Methods Mol Biol. 2015;1189:47-61
pubmed: 25245686
Circ Res. 2017 Mar 17;120(6):923-940
pubmed: 28302740
Development. 2019 Feb 20;146(4):
pubmed: 30787001
Front Cardiovasc Med. 2018 Aug 13;5:100
pubmed: 30151366
J Am Soc Echocardiogr. 2012 Apr;25(4):363-75
pubmed: 22284845
J Anat. 2016 Aug;229(2):314-25
pubmed: 27020702
Curr Opin Crit Care. 2007 Feb;13(1):73-8
pubmed: 17198052
Oxid Med Cell Longev. 2018 Aug 16;2018:5786742
pubmed: 30186545
Science. 1981 May 8;212(4495):671-2
pubmed: 7221553
Anat Rec. 2000 Apr 1;258(4):319-37
pubmed: 10737851
J Hum Genet. 2016 Jan;61(1):13-9
pubmed: 26223183
Pediatr Cardiol. 2010 Apr;31(3):422-9
pubmed: 20033147
Circ Res. 1998 May 18;82(9):936-46
pubmed: 9598591
J Cardiovasc Med (Hagerstown). 2008 Apr;9(4):368-74
pubmed: 18334891
J Hered. 2015;106 Suppl 1:469-77
pubmed: 26245782
Clin Sci (Lond). 2006 Jul;111(1):35-46
pubmed: 16764556
Front Pediatr. 2017 Jan 09;4:143
pubmed: 28119904
Front Physiol. 2015 Jun 08;6:176
pubmed: 26106333
Dev Cell. 2017 Sep 25;42(6):655-666.e3
pubmed: 28890073
Nat Rev Cardiol. 2011 Jan;8(1):50-60
pubmed: 21045784
Am Heart J. 2004 Mar;147(3):425-39
pubmed: 14999190
Circ Cardiovasc Genet. 2014 Aug;7(4):423-433
pubmed: 25028484
Dev Dyn. 2020 May;249(5):636-645
pubmed: 31900966
Dev Cell. 2018 Dec 17;47(6):680-681
pubmed: 30562506
Development. 2016 Jul 15;143(14):2561-72
pubmed: 27436040
Pediatr Cardiol. 2010 Feb;31(2):250-63
pubmed: 20024652
Dev Neurosci. 2016;38(5):311-330
pubmed: 28152539
Circulation. 2011 Mar 1;123(8):841-9
pubmed: 21321151
Echocardiography. 2017 Dec;34(12):1822-1833
pubmed: 29287137
Hum Reprod. 1992 May;7(5):701-10
pubmed: 1639991
Nature. 2010 Mar 25;464(7288):549-53
pubmed: 20336138
J Am Heart Assoc. 2014 May 22;3(3):e000841
pubmed: 24855117
Cardiovasc Res. 2011 Jul 15;91(2):289-99
pubmed: 21285290
Biochem Genet. 2017 Apr;55(2):105-123
pubmed: 27807680
J Am Coll Cardiol. 2017 Feb 21;69(7):859-870
pubmed: 28209227
PLoS One. 2018 Sep 12;13(9):e0202474
pubmed: 30208049
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5722-3
pubmed: 6946511
Semin Fetal Neonatal Med. 2010 Feb;15(1):46-51
pubmed: 19540822
Cardiovasc Res. 2004 Oct 1;64(1):40-51
pubmed: 15364612
Circulation. 1998 Jan 27;97(3):257-62
pubmed: 9462527
J Clin Invest. 2017 Jun 1;127(6):2235-2248
pubmed: 28436940
Mol Cell Biol. 2011 Nov;31(22):4633-45
pubmed: 21930795
Cell. 2012 Nov 21;151(5):1083-96
pubmed: 23178125