Maternal First-Trimester Cow-Milk Intake Is Positively Associated with Childhood General and Abdominal Visceral Fat Mass and Lean Mass but Not with Other Cardiometabolic Risk Factors at the Age of 10 Years.
body fat
body mass index
childhood
lean mass
liver fat
maternal milk intake during pregnancy
pericardial fat mass
visceral fat mass
Journal
The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
17
09
2020
revised:
17
12
2020
accepted:
10
02
2021
pubmed:
25
3
2021
medline:
29
1
2022
entrez:
24
3
2021
Statut:
ppublish
Résumé
Higher maternal cow-milk intake during pregnancy is associated with higher fetal growth measures and higher birth weight. The aim of this study was to assess the associations of maternal milk intake during pregnancy with body fat measures and cardiometabolic risk factors at the age of 10 y. In a population-based cohort of Dutch mothers and their children (n = 2466) followed from early pregnancy onwards, we assessed maternal first-trimester milk intake (milk and milk drinks) by food-frequency questionnaire. Maternal milk intake was categorized into 0-0.9, 1-1.9, 2-2.9, 3-3.9, 4-4.9, and ≥5 glasses/d, with 1 glass equivalent to 150 mL milk. For children at the age of 10 y, we calculated BMI and obtained detailed measures of body and organ fat by DXA and MRI. We also measured blood pressure and lipid, insulin, and glucose concentrations. Data were analyzed using linear and logistic regression models. Compared with children whose mothers consumed 0-0.9 glass of milk/d during their pregnancy, those whose mothers consumed ≥5 glasses of milk/d had a 0.29 SD (95% CI: 0.10, 0.48) higher BMI, 0.27 SD (95% CI: 0.08, 0.47) higher fat mass, 0.26 SD (95% CI: 0.07, 0.46) higher lean mass, 0.30 SD (95% CI: 0.09, 0.50) higher android-to-gynoid fat mass ratio and 0.38 SD (95% CI: 0.09, 0.67) higher abdominal visceral fat mass. After correction for multiple comparisons, groups of maternal milk intake were not associated with pericardial fat mass index, liver fat fraction, blood pressure, or lipid, insulin, or glucose concentrations (P values >0.0125). Our results suggest that maternal first-trimester milk intake is positively associated with childhood general and abdominal visceral fat mass and lean mass, but not with other cardiometabolic risk factors.
Sections du résumé
BACKGROUND
Higher maternal cow-milk intake during pregnancy is associated with higher fetal growth measures and higher birth weight.
OBJECTIVE
The aim of this study was to assess the associations of maternal milk intake during pregnancy with body fat measures and cardiometabolic risk factors at the age of 10 y.
METHODS
In a population-based cohort of Dutch mothers and their children (n = 2466) followed from early pregnancy onwards, we assessed maternal first-trimester milk intake (milk and milk drinks) by food-frequency questionnaire. Maternal milk intake was categorized into 0-0.9, 1-1.9, 2-2.9, 3-3.9, 4-4.9, and ≥5 glasses/d, with 1 glass equivalent to 150 mL milk. For children at the age of 10 y, we calculated BMI and obtained detailed measures of body and organ fat by DXA and MRI. We also measured blood pressure and lipid, insulin, and glucose concentrations. Data were analyzed using linear and logistic regression models.
RESULTS
Compared with children whose mothers consumed 0-0.9 glass of milk/d during their pregnancy, those whose mothers consumed ≥5 glasses of milk/d had a 0.29 SD (95% CI: 0.10, 0.48) higher BMI, 0.27 SD (95% CI: 0.08, 0.47) higher fat mass, 0.26 SD (95% CI: 0.07, 0.46) higher lean mass, 0.30 SD (95% CI: 0.09, 0.50) higher android-to-gynoid fat mass ratio and 0.38 SD (95% CI: 0.09, 0.67) higher abdominal visceral fat mass. After correction for multiple comparisons, groups of maternal milk intake were not associated with pericardial fat mass index, liver fat fraction, blood pressure, or lipid, insulin, or glucose concentrations (P values >0.0125).
CONCLUSIONS
Our results suggest that maternal first-trimester milk intake is positively associated with childhood general and abdominal visceral fat mass and lean mass, but not with other cardiometabolic risk factors.
Identifiants
pubmed: 33758934
pii: S0022-3166(22)00249-8
doi: 10.1093/jn/nxab047
pmc: PMC8245880
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1965-1975Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
Références
Ann Nutr Metab. 2019;74(2):93-106
pubmed: 30673669
Blood Press Monit. 2006 Oct;11(5):281-91
pubmed: 16932037
Eur J Epidemiol. 2006;21(6):475-84
pubmed: 16826450
J Magn Reson Imaging. 2011 Oct;34(4):729-749
pubmed: 22025886
J Transl Med. 2015 Jan 16;13:13
pubmed: 25592553
Pediatr Obes. 2020 May;15(5):e12607
pubmed: 31883239
Adv Nutr. 2018 May 1;10(suppl_2):S74-S87
pubmed: 31089739
Eur J Epidemiol. 2016 Dec;31(12):1243-1264
pubmed: 28070760
Br J Nutr. 2013 Oct;110(8):1454-64
pubmed: 23528150
Hypertension. 2014 Aug;64(2):266-74
pubmed: 24866145
Eur J Nutr. 2017 Sep;56(6):2151-2160
pubmed: 27376355
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Oxid Med Cell Longev. 2017;2017:6018675
pubmed: 28770023
Adipocyte. 2013 Jul 1;2(3):128-34
pubmed: 23991358
Food Nutr Res. 2012;56:
pubmed: 23185146
Eur J Clin Nutr. 2013 Oct;67(10):1036-41
pubmed: 24002041
Int J Obes (Lond). 2014 Jul;38(7):966-72
pubmed: 24448598
Biol Sex Differ. 2012 May 31;3(1):13
pubmed: 22651247
J Dev Orig Health Dis. 2015 Dec;6(6):485-92
pubmed: 26434993
Paediatr Perinat Epidemiol. 2016 May;30(3):274-84
pubmed: 26945670
N Engl J Med. 2008 Jul 3;359(1):61-73
pubmed: 18596274
Am J Clin Nutr. 2011 Aug;94(2):501-9
pubmed: 21697074
J Epidemiol Community Health. 2005 Jun;59(6):467-72
pubmed: 15911641
BMJ. 2000 May 6;320(7244):1240-3
pubmed: 10797032
Acta Radiol. 2018 Oct;59(10):1203-1209
pubmed: 29444586
Am J Phys Anthropol. 2002;Suppl 35:159-84
pubmed: 12653312
Pediatr Radiol. 2009 Jul;39(7):647-56
pubmed: 19415261
Nutrients. 2019 Feb 20;11(2):
pubmed: 30791647
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
PLoS Med. 2019 Feb 11;16(2):e1002744
pubmed: 30742624
N Engl J Med. 2020 Feb 13;382(7):644-654
pubmed: 32053300
Diseases. 2017 Mar 15;5(1):
pubmed: 28933365
Pediatr Res. 2000 Mar;47(3):316-23
pubmed: 10709729
Curr Biol. 2009 Dec 1;19(22):R1046-52
pubmed: 19948145
Proc Nutr Soc. 2006 Feb;65(1):97-105
pubmed: 16441949
Nutrients. 2020 May 08;12(5):
pubmed: 32397149
Environ Health Perspect. 2014 Jul;122(7):761-7
pubmed: 24695368
Circulation. 2009 Feb 3;119(4):628-47
pubmed: 19139390
Circulation. 2007 Jul 3;116(1):39-48
pubmed: 17576866
Eur J Epidemiol. 2014 Dec;29(12):911-27
pubmed: 25527369
Int J Obes Relat Metab Disord. 2002 Jul;26(7):947-52
pubmed: 12080448
Circulation. 2011 Dec 13;124(24):e837-41
pubmed: 22156000
Obes Rev. 2011 May;12(5):e504-15
pubmed: 21348916
Nutrition. 2014 Jun;30(6):619-27
pubmed: 24800664
J Health Popul Nutr. 2013 Dec;31(4):435-45
pubmed: 24592584
Eur J Clin Nutr. 1998 Aug;52(8):588-96
pubmed: 9725660
Nutr J. 2013 Jul 25;12:103
pubmed: 23883112
Am J Clin Nutr. 2007 Oct;86(4):1104-10
pubmed: 17921389
Am J Clin Nutr. 1990 Dec;52(6):953-9
pubmed: 2239792