Evaluation of the efficacy of enrofloxacin in rainbow trout (Oncorhynchus mykiss) following experimental challenge with Yersinia ruckeri.
Yersinia ruckeri
challenge model
enrofloxacin
rainbow trout
yersiniosis
Journal
The Veterinary record
ISSN: 2042-7670
Titre abrégé: Vet Rec
Pays: England
ID NLM: 0031164
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
05
12
2020
received:
23
07
2020
accepted:
08
02
2021
pubmed:
25
3
2021
medline:
3
8
2021
entrez:
24
3
2021
Statut:
ppublish
Résumé
Use of enrofloxacin in trout farms is reported, especially for the treatment of yersiniosis, albeit various dosing regimens have been used. Therefore, optimal doses should be investigated. Five groups of 15 fish were challenged with Y. ruckeri. Two days later, three groups received feed containing enrofloxacin (ENR) at 1, 2.5 and 5 mg/kg fish respectively, during 7 days; one group received a single intraperitoneal injection of ENR at 10 mg/kg; and one group was left untreated. On day 15, surviving fish were euthanized. All fish survived in the group treated by injection, compared to 53%, 60% and 40% of the fish treated with 1, 2.5 and 5 mg/kg oral ENR, respectively, and 53% in the infected untreated group. A single intraperitoneal injection of ENR at 10 mg/kg seems more relevant than repeated oral administrations. The ENR oral doses used in trout farms should be revised.
Sections du résumé
BACKGROUND
BACKGROUND
Use of enrofloxacin in trout farms is reported, especially for the treatment of yersiniosis, albeit various dosing regimens have been used. Therefore, optimal doses should be investigated.
METHODS
METHODS
Five groups of 15 fish were challenged with Y. ruckeri. Two days later, three groups received feed containing enrofloxacin (ENR) at 1, 2.5 and 5 mg/kg fish respectively, during 7 days; one group received a single intraperitoneal injection of ENR at 10 mg/kg; and one group was left untreated. On day 15, surviving fish were euthanized.
RESULTS
RESULTS
All fish survived in the group treated by injection, compared to 53%, 60% and 40% of the fish treated with 1, 2.5 and 5 mg/kg oral ENR, respectively, and 53% in the infected untreated group.
CONCLUSION
CONCLUSIONS
A single intraperitoneal injection of ENR at 10 mg/kg seems more relevant than repeated oral administrations. The ENR oral doses used in trout farms should be revised.
Substances chimiques
Enrofloxacin
3DX3XEK1BN
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e200Subventions
Organisme : France-AGRIMER
Organisme : CIPA, FEP and the regions of Aquitaine
Organisme : Brittany and Pays de la Loire
ID : CIM 6008-1420
Informations de copyright
© 2021 British Veterinary Association.
Références
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