Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells.
Alarmins
/ metabolism
Apoptosis
/ drug effects
Cell Line, Tumor
Colorectal Neoplasms
/ drug therapy
Female
HaCaT Cells
Humans
Hydrogen Peroxide
/ pharmacology
Hyperthermic Intraperitoneal Chemotherapy
/ methods
Hypochlorous Acid
/ pharmacology
Mitochondria
/ drug effects
Ovarian Neoplasms
/ drug therapy
Oxidation-Reduction
/ drug effects
Pancreatic Neoplasms
/ drug therapy
Peritoneal Neoplasms
/ drug therapy
Peritoneum
/ drug effects
Peroxynitrous Acid
/ pharmacology
calreticulin
heat‑shock protein
peritoneal carcinomatosis
reactive oxygen species
Journal
Oncology reports
ISSN: 1791-2431
Titre abrégé: Oncol Rep
Pays: Greece
ID NLM: 9422756
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
16
06
2020
accepted:
18
01
2021
entrez:
24
3
2021
pubmed:
25
3
2021
medline:
3
11
2021
Statut:
ppublish
Résumé
Tumors of the abdominal cavity, such as colorectal, pancreatic and ovarian cancer, frequently metastasize into the peritoneum. Large numbers of metastatic nodules hinder curative surgical resection, necessitating lavage with hyperthermic intraperitoneal chemotherapy (HIPEC). However, HIPEC not only causes severe side effects but also has limited therapeutic efficacy in various instances. At the same time, the age of immunotherapies such as biological agents, checkpoint‑ inhibitors or immune‑cell therapies, increasingly emphasizes the critical role of anticancer immunity in targeting malignancies. The present study investigated the ability of three types of long‑lived reactive species (oxidants) to inactivate cancer cells and potentially complement current HIPEC regimens, as well as to increase tumor cell expression of danger signals that stimulate innate immunity. The human abdominal cancer cell lines HT‑29, Panc‑01 and SK‑OV‑3 were exposed to different concentrations of hydrogen peroxide (H
Identifiants
pubmed: 33760187
doi: 10.3892/or.2021.8022
pii: 71
pmc: PMC8020206
doi:
pii:
Substances chimiques
Alarmins
0
Peroxynitrous Acid
14691-52-2
Hypochlorous Acid
712K4CDC10
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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