Archaeogenomic distinctiveness of the Isthmo-Colombian area.
Central America
Isthmian populations
Panama
ancient and modern DNA
anthropology and history
archaeogenomics
archaeology
genomic variation
indigenous Americans
population genetics
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
08
07
2020
revised:
20
10
2020
accepted:
18
02
2021
pubmed:
25
3
2021
medline:
21
10
2021
entrez:
24
3
2021
Statut:
ppublish
Résumé
The recently enriched genomic history of Indigenous groups in the Americas is still meager concerning continental Central America. Here, we report ten pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven groups presently living in Panama. Our analyses reveal that pre-Hispanic demographic events contributed to the extensive genetic structure currently seen in the area, which is also characterized by a distinctive Isthmo-Colombian Indigenous component. This component drives these populations on a specific variability axis and derives from the local admixture of different ancestries of northern North American origin(s). Two of these ancestries were differentially associated to Pleistocene Indigenous groups that also moved into South America, leaving heterogenous genetic footprints. An additional Pleistocene ancestry was brought by a still unsampled population of the Isthmus (UPopI) that remained restricted to the Isthmian area, expanded locally during the early Holocene, and left genomic traces up to the present day.
Identifiants
pubmed: 33761327
pii: S0092-8674(21)00229-4
doi: 10.1016/j.cell.2021.02.040
pmc: PMC8024902
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1706-1723.e24Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098386/Z/12/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Am J Hum Genet. 2013 Aug 8;93(2):278-88
pubmed: 23910464
PLoS Genet. 2019 Jul 26;15(7):e1008302
pubmed: 31348818
Mol Ecol Resour. 2015 Sep;15(5):1179-91
pubmed: 25684545
Sci Rep. 2019 May 9;9(1):6850
pubmed: 31073131
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14308-13
pubmed: 23940335
Nat Genet. 2018 Oct;50(10):1426-1434
pubmed: 30224645
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15758-63
pubmed: 24019490
Nature. 2014 Sep 18;513(7518):409-13
pubmed: 25230663
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9469-9474
pubmed: 30988179
Genetics. 2016 Apr;202(4):1485-501
pubmed: 26857625
Syst Biol. 2018 Sep 1;67(5):901-904
pubmed: 29718447
Nucleic Acids Res. 2002 Jul 15;30(14):3059-66
pubmed: 12136088
Genome Biol. 2016 Mar 31;17:60
pubmed: 27036623
Genome Res. 2010 Sep;20(9):1174-9
pubmed: 20587512
Curr Opin Genet Dev. 2016 Dec;41:27-35
pubmed: 27507099
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Science. 1975 Jan 17;187(4172):137-45
pubmed: 17736527
Nature. 2015 Mar 19;519(7543):309-314
pubmed: 25788095
Nature. 2019 Jun;570(7760):236-240
pubmed: 31168094
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
PLoS Comput Biol. 2019 Apr 8;15(4):e1006650
pubmed: 30958812
Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6774-6779
pubmed: 29895688
Sci Rep. 2020 Jul 1;10(1):10700
pubmed: 32612271
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Mol Biol Evol. 2020 Sep 1;37(9):2503-2519
pubmed: 32344428
Nature. 2010 Sep 2;467(7311):52-8
pubmed: 20811451
Science. 2018 Dec 7;362(6419):
pubmed: 30409807
Sci Adv. 2016 Apr 01;2(4):e1501385
pubmed: 27051878
Curr Biol. 2015 Nov 2;25(21):2878
pubmed: 28843288
PLoS One. 2012;7(6):e38337
pubmed: 22675545
PLoS One. 2015 Jun 18;10(6):e0129102
pubmed: 26086078
Cell. 2008 Aug 8;134(3):416-26
pubmed: 18692465
Curr Biol. 2013 Apr 8;23(7):553-559
pubmed: 23523248
Nature. 2012 Aug 16;488(7411):370-4
pubmed: 22801491
Nat Commun. 2018 Dec 19;9(1):5388
pubmed: 30568240
Am J Hum Genet. 1990 Jan;46(1):63-84
pubmed: 2294755
Sci Adv. 2019 Sep 04;5(9):eaaw3492
pubmed: 31517044
PLoS One. 2013 Aug 21;8(8):e71390
pubmed: 23990949
Curr Biol. 2017 Feb 20;27(4):576-582
pubmed: 28162894
Nature. 2019 Jun;570(7760):182-188
pubmed: 31168093
PLoS One. 2016 Oct 5;11(10):e0163019
pubmed: 27706187
Nat Genet. 2016 Jun;48(6):593-9
pubmed: 27111036
PLoS Biol. 2013;11(5):e1001555
pubmed: 23667324
Cell. 2020 May 28;181(5):1131-1145.e21
pubmed: 32386546
Eur J Hum Genet. 2017 May;25(5):631-636
pubmed: 28272540
Sci Adv. 2017 May 24;3(5):e1602778
pubmed: 28560337
Mol Biol Evol. 2019 Jun 1;36(6):1254-1269
pubmed: 30895292
Curr Biol. 2009 Jan 13;19(1):1-8
pubmed: 19135370
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2341-2346
pubmed: 29463742
Genome Res. 2018 Jun;28(6):767-779
pubmed: 29735605
Bioinformatics. 2020 Feb 1;36(3):828-841
pubmed: 31504166
Nature. 2021 Feb;590(7844):103-110
pubmed: 33361817
Curr Biol. 2019 Dec 2;29(23):3974-3986.e4
pubmed: 31735679
Nature. 2008 Nov 6;456(7218):98-101
pubmed: 18758442
PLoS Genet. 2013 Nov;9(11):e1003925
pubmed: 24244192
PLoS One. 2016 Sep 28;11(9):e0162870
pubmed: 27683248
PLoS Genet. 2015 Dec 04;11(12):e1005602
pubmed: 26636962
Genetics. 2012 Nov;192(3):1065-93
pubmed: 22960212
Bioinformatics. 2013 Jul 01;29(13):1682-4
pubmed: 23613487
Nat Commun. 2015 Mar 24;6:6596
pubmed: 25803618
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
BMC Biol. 2019 Jan 24;17(1):3
pubmed: 30674303
PLoS Genet. 2012;8(11):e1002967
pubmed: 23166502
Science. 2017 Nov 3;358(6363):592-594
pubmed: 29097536
Nucleic Acids Res. 2016 Jul 8;44(W1):W58-63
pubmed: 27084951
Science. 2020 Jul 24;369(6502):456-460
pubmed: 32499399
PLoS Genet. 2006 Dec;2(12):e190
pubmed: 17194218
Proc Biol Sci. 2012 Dec 7;279(1748):4724-33
pubmed: 23055061
PLoS Genet. 2012 Jan;8(1):e1002453
pubmed: 22291602
Nature. 2020 Aug;584(7819):93-97
pubmed: 32699413
Mol Ecol Resour. 2020 Nov;20(6):1658-1667
pubmed: 32717097
Science. 2018 Jun 1;360(6392):1024-1027
pubmed: 29853687
PLoS One. 2007 Sep 05;2(9):e829
pubmed: 17786201
Am J Hum Genet. 2009 Jun;84(6):740-59
pubmed: 19500773
PLoS Genet. 2018 May 24;14(5):e1007385
pubmed: 29795556
BMC Bioinformatics. 2014 Nov 25;15:356
pubmed: 25420514
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Mol Biol Evol. 2005 May;22(5):1185-92
pubmed: 15703244
PLoS One. 2020 Jul 22;15(7):e0236023
pubmed: 32697794
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4093-4098
pubmed: 28377518
Cell. 2018 Nov 15;175(5):1185-1197.e22
pubmed: 30415837
Mol Biol Evol. 2018 Feb 1;35(2):299-311
pubmed: 29099937
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Science. 2018 Jun 1;360(6392):964-965
pubmed: 29853673
Curr Biol. 2019 May 20;29(10):1701-1711.e16
pubmed: 31080083
Curr Biol. 2019 Jan 7;29(1):149-157.e3
pubmed: 30581024
Nat Genet. 1999 Oct;23(2):147
pubmed: 10508508
Curr Biol. 2016 Mar 21;26(6):827-33
pubmed: 26853362
Am J Hum Genet. 2004 Nov;75(5):910-8
pubmed: 15382008
Hum Biol. 1994 Dec;66(6):963-77
pubmed: 7835876
Bioinformatics. 2010 Nov 15;26(22):2867-73
pubmed: 20926424
Nature. 2016 Aug 25;536(7617):419-24
pubmed: 27459054
Genetics. 2013 Jun;194(2):459-71
pubmed: 23535385
Science. 2019 Jul 12;365(6449):
pubmed: 31296740
Cell. 2020 Jun 11;181(6):1232-1245.e20
pubmed: 32437661
Nat Methods. 2011 Dec 04;9(2):179-81
pubmed: 22138821
Science. 2014 Jun 13;344(6189):1280-5
pubmed: 24926019
PLoS One. 2018 Apr 23;13(4):e0195491
pubmed: 29684051
Mol Biol Evol. 2017 May 1;34(5):1230-1239
pubmed: 28177087
PLoS One. 2015 Dec 04;10(12):e0144223
pubmed: 26636572
Nature. 2015 Sep 3;525(7567):104-8
pubmed: 26196601
Genome Biol. 2015 Oct 12;16:224
pubmed: 26458810
Nature. 2020 Aug;584(7819):87-92
pubmed: 32699412