Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 03 2021
24 03 2021
Historique:
received:
21
09
2020
accepted:
03
03
2021
entrez:
25
3
2021
pubmed:
26
3
2021
medline:
25
2
2023
Statut:
epublish
Résumé
In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53-84 years) have been investigated using the Trail Making Test (TMT) and functional near-infrared spectroscopy in a block design. We investigated effects of age on the performance and cortical blood oxygenation during the TMT. Since it is assumed that older people may compensate for cognitive deficits by slowing their processing speed, we additionally analyzed the cortical blood oxygenation per solved item. Our results showed a significant decrease in processing speed in older participants compared to middle-aged individuals, however, also lower error rates during TMT part A. On a neurophysiological level, we observed increased cortical blood oxygenation in the older participants when completing the TMT. Finally, with respect to the combined measurement (O
Identifiants
pubmed: 33762595
doi: 10.1038/s41598-021-85762-w
pii: 10.1038/s41598-021-85762-w
pmc: PMC7991654
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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