Combined inhibition of Aurora-A and ATR kinase results in regression of

Animals Apoptosis / genetics Aurora Kinase A / genetics Cell Line, Tumor Mice N-Myc Proto-Oncogene Protein / genetics Neuroblastoma / drug therapy

Journal

Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119

Informations de publication

Date de publication:
03 2021
Historique:
entrez: 26 3 2021
pubmed: 27 3 2021
medline: 27 3 2021
Statut: ppublish

Résumé

Amplification of

Identifiants

DOI: 10.1038/s43018-020-00171-8 PMID: 33768209 PMC: PMC7610389
pubmed: 33768209
doi: 10.1038/s43018-020-00171-8
pmc: PMC7610389
mid: EMS116978
doi:

Substances chimiques

N-Myc Proto-Oncogene Protein 0
Aurora Kinase A EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

312-326

Subventions

Organisme : European Research Council
ID : 669771
Pays : International
Organisme : Cancer Research UK
ID : A16464
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A23302
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A14610
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A18339
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_16047
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_18051
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom

Déclaration de conflit d'intérêts

Conflict of Interest The authors declare no competing interests.

Références

Cancer Discov. 2018 Feb;8(2):150-163
pubmed: 29358508
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Mol Cell. 2016 Jan 7;61(1):54-67
pubmed: 26687678
BMC Genomics. 2014 Apr 15;15:284
pubmed: 24735413
Nucleic Acids Res. 2020 Aug 20;48(14):7844-7855
pubmed: 32652013
Cell Rep. 2013 May 30;3(5):1651-62
pubmed: 23684611
Mol Cell. 2018 Feb 15;69(4):648-663.e7
pubmed: 29398447
Mol Cancer Ther. 2007 Sep;6(9):2399-408
pubmed: 17876039
Nat Commun. 2020 Feb 14;11(1):913
pubmed: 32060267
Cell. 2012 Sep 28;151(1):68-79
pubmed: 23021216
Mol Cell. 2012 Mar 30;45(6):814-25
pubmed: 22387027
Nat Rev Mol Cell Biol. 2020 May;21(5):255-267
pubmed: 32071436
Nature. 2018 Jul;559(7713):279-284
pubmed: 29950726
Cancer Cell. 2009 Jan 6;15(1):67-78
pubmed: 19111882
Cell. 2010 Aug 20;142(4):625-36
pubmed: 20705336
Clin Cancer Res. 2011 Dec 15;17(24):7614-24
pubmed: 22016509
ACS Chem Biol. 2010 Jun 18;5(6):563-76
pubmed: 20426425
Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):591-602
pubmed: 17255282
Cold Spring Harb Symp Quant Biol. 2004;69:273-80
pubmed: 16117659
Nature. 2019 Mar;567(7749):545-549
pubmed: 30894746
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16856-61
pubmed: 24082115
Clin Cancer Res. 2019 Jun 1;25(11):3229-3238
pubmed: 30777875
Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27
pubmed: 18594563
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731
pubmed: 27837025
Cancer Cell. 2013 Jul 8;24(1):75-89
pubmed: 23792191
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Mol Cancer Ther. 2010 Jan;9(1):157-66
pubmed: 20053775
Nature. 2008 Oct 2;455(7213):679-83
pubmed: 18716624
Mol Cell. 2013 Nov 21;52(4):583-90
pubmed: 24211264
Clin Cancer Res. 2019 Jan 1;25(1):43-51
pubmed: 30232224
Curr Biol. 2002 Jul 9;12(13):R458-60
pubmed: 12121637
Nature. 2014 Jul 24;511(7510):488-492
pubmed: 25043028
Genes Dev. 2007 Nov 1;21(21):2818-31
pubmed: 17942706
Mol Cell. 2014 Dec 18;56(6):777-85
pubmed: 25435140
Nat Rev Immunol. 2015 Dec;15(12):760-70
pubmed: 26603901
Chromosoma. 2019 Mar;128(1):41-52
pubmed: 30612150
Mol Cell. 2012 May 11;46(3):311-24
pubmed: 22483619
Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10258-63
pubmed: 23733953
Nat Commun. 2012;3:994
pubmed: 22871813
J Cell Biol. 2010 Dec 27;191(7):1315-32
pubmed: 21187329
Cell. 2012 Sep 28;151(1):56-67
pubmed: 23021215
Genes Dev. 2019 Sep 1;33(17-18):1252-1264
pubmed: 31395740
Science. 2010 Oct 8;330(6001):231-5
pubmed: 20705812
J Biol Chem. 2000 Sep 15;275(37):28345-8
pubmed: 10906320
Nat Rev Cancer. 2018 Sep;18(9):586-595
pubmed: 29899559
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Cell Rep. 2017 Dec 19;21(12):3483-3497
pubmed: 29262328
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nat Chem Biol. 2007 Sep;3(9):570-5
pubmed: 17643112
Cell. 2012 Mar 30;149(1):22-35
pubmed: 22464321
Nat Chem Biol. 2018 Feb;14(2):163-170
pubmed: 29251720
Nature. 2014 Jul 24;511(7510):483-7
pubmed: 25043018
Cell. 2008 Jun 13;133(6):1106-17
pubmed: 18555785
Mol Cell. 2020 Mar 19;77(6):1322-1339.e11
pubmed: 32006464
Nat Commun. 2018 Jul 11;9(1):2678
pubmed: 29992957
Cancer Cell. 2014 Sep 8;26(3):414-427
pubmed: 25175806
Nat Genet. 2018 Apr;50(4):515-523
pubmed: 29379199
EMBO J. 1997 Jun 2;16(11):2985-95
pubmed: 9214616
Biochem Biophys Res Commun. 2016 Jan 1;469(1):22-28
pubmed: 26607113
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W187-91
pubmed: 24799436
Curr Protoc Bioinformatics. 2014 Sep 08;47:11.12.1-34
pubmed: 25199790
Nat Struct Mol Biol. 2016 Jun;23(6):540-8
pubmed: 27159561
Clin Cancer Res. 2007 Jun 15;13(12):3682-8
pubmed: 17575233
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
J Med Chem. 2018 Nov 21;61(22):9889-9907
pubmed: 30346772
Cell. 2016 Dec 1;167(6):1455-1467
pubmed: 27912056
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
J Cell Biol. 2002 Aug 19;158(4):617-23
pubmed: 12177045
J Immunol Methods. 1986 May 1;89(1):123-30
pubmed: 2422282
Biochem J. 2010 Mar 15;427(1):19-28
pubmed: 20067443
Science. 2017 Dec 1;358(6367):
pubmed: 29191878
Sci Transl Med. 2017 Nov 1;9(414):
pubmed: 29093183
Clin Cancer Res. 2018 Dec 15;24(24):6142-6149
pubmed: 30093449
Cell. 2017 Aug 10;170(4):774-786.e19
pubmed: 28802045
Nature. 2019 Aug;572(7771):676-680
pubmed: 31391581
Cell. 2017 Nov 30;171(6):1301-1315.e14
pubmed: 29195074

Auteurs

Isabelle Roeschert (I)

Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

Evon Poon (E)

Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, The Royal Marsden NHS Trust, 15 Cotswold Rd. Belmont, Sutton, Surrey SM2 5NG, UK.

Anton G Henssen (AG)

Experimental and Clinical Research Center, Max Delbrück Center and Charité Berlin, Lindenberger Weg 80, 13125 Berlin, Germany.

Heathcliff Dorado Garcia (HD)

Experimental and Clinical Research Center, Max Delbrück Center and Charité Berlin, Lindenberger Weg 80, 13125 Berlin, Germany.

Marco Gatti (M)

Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstraße 190, 8057 Zurich, Switzerland.

Celeste Giansanti (C)

Institute of Molecular Oncology, Center of Molecular Biosciences, University of Göttingen, Justus von Liebig Weg 11, 37077 Göttingen, Germany.

Yann Jamin (Y)

Divisions of Radiotherapy and Imaging, The Institute of Cancer Research, The Royal Marsden NHS Trust, 15 Cotswold Rd. Belmont, Sutton, Surrey SM2 5NG, UK.

Carsten P Ade (CP)

Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

Peter Gallant (P)

Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

Christina Schülein-Völk (C)

Theodor Boveri Institute, Core Unit High-Content Microscopy, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

Petra Beli (P)

Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.

Mark Richards (M)

Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Mathias Rosenfeldt (M)

Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.

Matthias Altmeyer (M)

Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstraße 190, 8057 Zurich, Switzerland.

John Anderson (J)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street London WC1N 1EH, UK.

Angelika Eggert (A)

Experimental and Clinical Research Center, Max Delbrück Center and Charité Berlin, Lindenberger Weg 80, 13125 Berlin, Germany.

Matthias Dobbelstein (M)

Institute of Molecular Oncology, Center of Molecular Biosciences, University of Göttingen, Justus von Liebig Weg 11, 37077 Göttingen, Germany.

Richard Bayliss (R)

Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Louis Chesler (L)

Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, The Royal Marsden NHS Trust, 15 Cotswold Rd. Belmont, Sutton, Surrey SM2 5NG, UK.

Gabriele Büchel (G)

Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Mildred Scheel Early Career Center, University Hospital Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany.

Martin Eilers (M)

Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Combined inhibition of Aurora-A and ATR kinase...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Combined inhibition of Aurora-A and ATR kinase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Aurora kinases › Aurora kinase A › Combined inhibition of Aurora-A and ATR kinase...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Combined inhibition of Aurora-A and ATR kinase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Combined inhibition of Aurora-A and ATR kinase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéine du proto-oncogène N-Myc › Combined inhibition of Aurora-A and ATR kinase...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › Combined inhibition of Aurora-A and ATR kinase...