Brenner Borderline Ovarian Tumor: A Case Series and Literature Review.
Journal
Annals of surgical oncology
ISSN: 1534-4681
Titre abrégé: Ann Surg Oncol
Pays: United States
ID NLM: 9420840
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
19
01
2021
accepted:
04
03
2021
pubmed:
27
3
2021
medline:
28
9
2021
entrez:
26
3
2021
Statut:
ppublish
Résumé
Most frequent borderline ovarian tumors are serous and mucinous subtypes. Less frequent borderline diseases are endometrioid, clear-cell, and Brenner tumors (BBOT). Very little is known about the latter subtype, and most studies include very short series or case reports. The aim of this study is to determine the prognosis of a continuous series of BBOT and analyze data published in the literature on this rare entity. A retrospective review of patients with BBOT treated or referred to our institutions was conducted. A centralized histological review by a reference pathologist and data on the clinical characteristics, management, and outcomes of patients were required for inclusion. Overall, 17 patients were identified. Median age was 62 (range 42-85) years. Six patients underwent unilateral salpingo-oophorectomy, and 11 bilateral salpingo-oophorectomy +/- hysterectomy and/or staging surgery. In total, 16 patients had unilateral tumor, and all patients had stage I disease. Stromal microinvasion was observed in three cases. Median follow-up was 60 months (range 7-118 months). One patient developed a recurrence in contralateral ovary after unilateral salpingo-oophorectomy. One patient had previous history of urothelial tumor. Peritoneal staging surgery is not required because all patients reported had stage I disease. One recurrence occurred. When reviewing all the 82 cases reported in the literature (including ours), 9% had previous history or synchronous urothelial tumor, suggesting the need to carefully check for urological disease in patients with BBOT.
Sections du résumé
BACKGROUND
BACKGROUND
Most frequent borderline ovarian tumors are serous and mucinous subtypes. Less frequent borderline diseases are endometrioid, clear-cell, and Brenner tumors (BBOT). Very little is known about the latter subtype, and most studies include very short series or case reports. The aim of this study is to determine the prognosis of a continuous series of BBOT and analyze data published in the literature on this rare entity.
PATIENTS AND METHODS
METHODS
A retrospective review of patients with BBOT treated or referred to our institutions was conducted. A centralized histological review by a reference pathologist and data on the clinical characteristics, management, and outcomes of patients were required for inclusion.
RESULTS
RESULTS
Overall, 17 patients were identified. Median age was 62 (range 42-85) years. Six patients underwent unilateral salpingo-oophorectomy, and 11 bilateral salpingo-oophorectomy +/- hysterectomy and/or staging surgery. In total, 16 patients had unilateral tumor, and all patients had stage I disease. Stromal microinvasion was observed in three cases. Median follow-up was 60 months (range 7-118 months). One patient developed a recurrence in contralateral ovary after unilateral salpingo-oophorectomy. One patient had previous history of urothelial tumor.
CONCLUSIONS
CONCLUSIONS
Peritoneal staging surgery is not required because all patients reported had stage I disease. One recurrence occurred. When reviewing all the 82 cases reported in the literature (including ours), 9% had previous history or synchronous urothelial tumor, suggesting the need to carefully check for urological disease in patients with BBOT.
Identifiants
pubmed: 33768396
doi: 10.1245/s10434-021-09879-y
pii: 10.1245/s10434-021-09879-y
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6714-6720Informations de copyright
© 2021. Society of Surgical Oncology.
Références
Brenner F. Das Oophoroma folliculare. Frankf Z Pathol. 1907;1:150–71.
Katz VL, Lentz GM, Lobo RA, Gershenson DM. Comprehensive gynecology. 5th edn. Philadelphia: Mosby Elsevier; 2007.
Cuatrecasas M, Catasus L, Palacios J, Prat J. Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. Am J Surg Pathol. 2009;33:556–67.
doi: 10.1097/PAS.0b013e318188b84c
Roth LM, Sternberg WH. Proliferating Brenner tumors. Cancer. 1971;27:687–93.
doi: 10.1002/1097-0142(197103)27:3<687::AID-CNCR2820270326>3.0.CO;2-C
Hallgrìmsson J, Scully RE. Borderline and malignant Brenner tumours of the ovary. A report of 15 cases. Acta Pathol Microbiol Scand Suppl. 1972;233:56–66.
Miles PA, Norris HJ. Proliferative and malignant Brenner tumors of the ovary. Cancer. 1972;30:174–6.
doi: 10.1002/1097-0142(197207)30:1<174::AID-CNCR2820300125>3.0.CO;2-D
Woodruff JD, Dietrich D, Genadry R, et al. Proliferative and malignant Brenner tumors. Review of 47 cases. Am J Obstet Gynecol 1981;141:118–125.
Roth LM, Dallenbach-Hellweg G, Czernobilsky B. Ovarian Brenner tumors. I. Metaplastic, proliferating, and of low malignant potential. Cancer 1985; 56:582–591.
WHO classification of tumors of female reproductive organs. IARC: Lyon; 2020. p. 73–74.
Lee KR, Tavassoli FA, Prat J, et al. Surface epithelial stromal tumors. Pathology and genetics: tumors of the breast and female genital organs. World Health Organization Classification of Tumors 2003. In: Tavassoli, FA.; Devilee, P., editors. Lyon: IARC Press; 2003. p. 140–3.
Kuhn E, Ayhan A, Shih Ie M, Seidman JD, Kurman RJ. The pathogenesis of borderline Brenner tumor: an immunohistochemical and molecular genetic analysis. Mod Pathol. 2014;27:231–7.
doi: 10.1038/modpathol.2013.142
Uzan C, Dufeu-Lefebvre M, Fauvet R, et al. Management and prognosis of borderline ovarian Brenner tumors. Int J Gynecol Cancer. 2012;22:1332–6.
doi: 10.1097/IGC.0b013e318267db2f
Albu DF, Albu CC, Goganau AM, et al. Borderline Brenner tumors associated with ovarian cyst—case presentation. Rom J Morphol Embryol. 2016;57:893–8.
pubmed: 27833989
Aoun F, Kourie HR, Sirtaine N, Hawaux E. Disappearance of upper urinary tract urothelial carcinoma after treatment of a borderline Brenner tumor: case report and literature review. Oncol Res Treat. 2015;38:379–81.
doi: 10.1159/000433488
Chia CC, Huang SC. A borderline Brenner tumor mimicks uterine fibroids. Taiw J Obst Gynecol. 2011;2011(50):103–5.
doi: 10.1016/j.tjog.2009.10.001
De Cecio R, Cantile M, Collina F, et al. Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study. J Ovarian Res. 2014;7:101.
doi: 10.1186/s13048-014-0101-7
Klasa L, Wydra D, Biernat W. Recurrence of Brenner ovary borderline tumor in the abdominal wall postoperative scar—a case report and research of the literature. Ginekol Pol. 2014;85:873–6.
doi: 10.17772/gp/1916
Takahama J, Ascher SM, Hirohashi S, et al. Borderline Brenner tumor of the ovary: MRI findings. Abdom Imaging. 2004;29:528–30.
doi: 10.1007/s00261-003-0145-4
Svenes KB, Eide J. Proliferative Brenner tumor or ovarian metastases? A case report. Cancer. 1984;53:2692–7.
doi: 10.1002/1097-0142(19840615)53:12<2692::AID-CNCR2820531222>3.0.CO;2-8
Hermanns B, Faridi A, Rath W, Fuzesi L, Schroder W. Differential diagnosis, prognostic factors, and clinical treatment of proliferative Brenner tumor of the ovary. Ultrastruct Pathol. 2000;24:191–6.
doi: 10.1080/01913120050132930
Garofalo G, Chintinne M, Thomas D, Bucella D, Buxant F. Conservative surgical treatment of a borderline ovarian Brenner tumour in a pre-menopausal woman with subsequent pregnancy: case report of a rare entity. J Obstet Gynaecol. 2020;40:578–9.
doi: 10.1080/01443615.2019.1600481
Vali S, Oumar M, Chavan M, Wise O, Sayasneh A. Atyical proliferative Brenner tumour of the ovary with liver metastases: a case report. Int J Reprod Contracept Obst Gynecol. 2019;8:4576.
doi: 10.18203/2320-1770.ijrcog20194898
Ziadi S, Trimeche M, Hammedi F, et al. Bilateral proliferating Brenner tumor of the ovary associated with recurrent urothelial carcinoma of the urinary bladder. N Am J Med Sci. 2010;2:39–41.
pubmed: 22624111
pmcid: 3354386
Colgan TJ, Norris HJ. Ovarian epithelial tumors of low malignant potential: a review. Int J Gynecol Pathol. 1983;1:367–82.
doi: 10.1097/00004347-198301040-00007
Russell P. The pathological assessment of ovarian neoplasms. I: introduction to the common “epithelial” tumours and analysis of benign “epithelial” tumours. Pathology 1979;11:5–26.
Lee M, Jung YW, Kim SW, Kim SH, Kim YT. Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases. J Gynecol Oncol. 2010;21:59–61.
doi: 10.3802/jgo.2010.21.1.59
Lu S, Pei F, Liao SL. Invasive urothelial carcinoma in bladder associated with bilateral benign ovarian Brenner tumor: report of a case. Zhonghua Bing Li Xue Za Zhi. 2009;38:485–6.
pubmed: 19781200