Low-normal doses of methiopropamine induce aggressive behaviour in mice.
Aggressive behaviour
Grey zone
Methamphetamine
Methiopropamine
New psychoactive substances
Violence
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
03
11
2020
accepted:
01
03
2021
pubmed:
27
3
2021
medline:
7
7
2021
entrez:
26
3
2021
Statut:
ppublish
Résumé
Recreational use of illicit methiopropamine (MPA) is a public health concern because it produces neurochemical effects comparable with those induced by methamphetamine (METH). The present study investigated the effects of MPA on the expression of an aggressive behaviour. Eighty CD-1 male mice, after receiving intraperitoneal injection of saline, MPA (0.01-10 mg/kg), METH (0.01-10 mg/kg), or AMPH (0.01-10 mg/kg), once a week over a 5-week period, underwent the resident-intruder test and spontaneous locomotor activity measurement. Results showed that all psychostimulants induce aggressive behaviour even at low doses, with a dose-dependent increase and a time-dependent sensitisation. MPA potency was similar to METH and superior to AMPH. Therefore, MPA-induced aggressive behaviour may appear even at MPA dosages free of cardiovascular or other behavioural adverse effects and could become a non-intentional side effect that users experience after increasing and repeating MPA consumption.
Identifiants
pubmed: 33770233
doi: 10.1007/s00213-021-05813-y
pii: 10.1007/s00213-021-05813-y
doi:
Substances chimiques
1-(2-thienyl)-2-(methylamino)propane
0
Central Nervous System Stimulants
0
Thiophenes
0
Methamphetamine
44RAL3456C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1847-1856Références
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