New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants.
Umbilicaria decussata
biological activity
clotting time
metabolic profiling
natural products
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
30
01
2021
accepted:
26
03
2021
pubmed:
28
3
2021
medline:
11
8
2021
entrez:
27
3
2021
Statut:
ppublish
Résumé
This study reports the in vitro anticoagulation activity of acetonic extract (AE) of 42 lichen species and the identification of potential bioavailable anticoagulant compounds from Umbilicaria decussata as a competent anticoagulant lichen species. Lichens' AEs were evaluated for their anticoagulant activity by monitoring activated partial thromboplastin time (APTT) and prothrombin time (PT) assays. A strong, positive correlation was observed between total phenolics concentration (TPC) of species and blood coagulation parameters. U. decussata was the only species with the longest clotting time in both APTT and PT assays. The research was moved forward by performing in vivo assays using rats. The results corroborated the dose-dependent impact of U. decussata's AE on rats' clotting time. Major secondary metabolites of U. decussata and their plasma-related bioavailability were also investigated using LC-ESI-MS/MS. Atranol, orsellinic acid, D-mannitol, lecanoric acid, and evernic acid were detected as possible bioavailable anticoagulants of U. decussata. Our findings suggest that U. decussata might be a potential anticoagulant lichen species that can be used for the prevention or treatment of coagulation-related issues such as cardiovascular diseases (CVDs).
Identifiants
pubmed: 33773025
doi: 10.1002/cbdv.202100080
doi:
Substances chimiques
Anticoagulants
0
Benzaldehydes
0
Hydroxybenzoates
0
Plant Extracts
0
Resorcinols
0
Salicylates
0
atranol
0
orsellinic acid
11XLA0494B
Mannitol
3OWL53L36A
lecanoric acid
480-56-8
evernic acid
537-09-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100080Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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