Creld1 regulates myocardial development and function.

Animals Biomarkers Cell Adhesion Molecules / genetics Extracellular Matrix Proteins / genetics Flow Cytometry Gene Expression Profiling Gene Expression Regulation, Developmental Heart / embryology Humans Mice, Knockout Myocardium / metabolism Organogenesis / genetics Single-Cell Analysis
Creld1 ECM Heart development Notch Trabeculation

Journal

Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322

Informations de publication

Date de publication:
07 2021
Historique:
received: 05 12 2020
revised: 25 02 2021
accepted: 18 03 2021
pubmed: 29 3 2021
medline: 11 1 2022
entrez: 28 3 2021
Statut: ppublish

Résumé

CRELD1 (Cysteine-Rich with EGF-Like Domains 1) is a risk gene for non-syndromic atrioventricular septal defects in human patients. In a mouse model, Creld1 has been shown to be essential for heart development, particularly in septum and valve formation. However, due to the embryonic lethality of global Creld1 knockout (KO) mice, its cell type-specific function during peri- and postnatal stages remains unknown. Here, we generated conditional Creld1 KO mice lacking Creld1 either in the endocardium (KO

Identifiants

DOI: 10.1016/j.yjmcc.2021.03.008 PMID: 33773996
pubmed: 33773996
pii: S0022-2828(21)00065-1
doi: 10.1016/j.yjmcc.2021.03.008
pii:
doi:

Substances chimiques

Biomarkers 0
CRELD1 protein, mouse 0
Cell Adhesion Molecules 0
Extracellular Matrix Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-56

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Vera Beckert (V)

Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, 53127 Bonn, Germany.

Sebastian Rassmann (S)

Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, 53127 Bonn, Germany.

Amir Hossein Kayvanjoo (AH)

Life & Medical Institute (LIMES), Developmental Biology of the Immune System, University of Bonn, 53115 Bonn, Germany.

Christina Klausen (C)

Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, 53127 Bonn, Germany.

Lorenzo Bonaguro (L)

Life & Medical Institute (LIMES), Genomics and Immunoregulation, University of Bonn, 53115 Bonn, Germany.

Dominik Simon Botermann (DS)

Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, 53127 Bonn, Germany.

Melanie Krause (M)

Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, 53127 Bonn, Germany.

Kristin Moreth (K)

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Nadine Spielmann (N)

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Patricia da Silva-Buttkus (P)

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Helmut Fuchs (H)

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Valerie Gailus-Durner (V)

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Martin Hrabě de Angelis (MH)

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technical University Munich, 85354 Freising, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

Kristian Händler (K)

German Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Single Cell Genomics and Epigenomics at the DZNE and the University of Bonn, 53127 Bonn, Germany.

Thomas Ulas (T)

Life & Medical Institute (LIMES), Genomics and Immunoregulation, University of Bonn, 53115 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), PRECISE Platform for Single Cell Genomics and Epigenomics at the DZNE and the University of Bonn, 53127 Bonn, Germany.

Anna C Aschenbrenner (AC)

Life & Medical Institute (LIMES), Genomics and Immunoregulation, University of Bonn, 53115 Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6500HB Nijmegen, the Netherlands.

Elvira Mass (E)

Life & Medical Institute (LIMES), Developmental Biology of the Immune System, University of Bonn, 53115 Bonn, Germany. Electronic address: emass@uni-bonn.de.

Dagmar Wachten (D)

Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, 53127 Bonn, Germany. Electronic address: dwachten@uni-bonn.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Système cardiovasculaire › Coeur › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Organogenèse › Creld1 regulates myocardial development and function.
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Creld1 regulates myocardial development and function.