Nanotechnology synergized immunoengineering for cancer.
Adjuvants
Biomaterials
Cancer treatment
Imaging
Immunotherapy
Nanoparticles
Theranostic
Tumor
Vaccines
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
16
12
2020
revised:
06
03
2021
accepted:
15
03
2021
pubmed:
29
3
2021
medline:
23
11
2021
entrez:
28
3
2021
Statut:
ppublish
Résumé
Novel strategies modulating the immune system yielded enhanced anticancer responses and improved cancer survival. Nevertheless, the success rate of immunotherapy in cancer treatment has been below expectation(s) due to unpredictable efficacy and off-target effects from systemic dosing of immunotherapeutic(s). As a result, there is an unmet clinical need for improving conventional immunotherapy. Nanotechnology offers several new strategies, multimodality, and multiplex biological targeting advantage to overcome many of these challenges. These efforts enable programming the pharmacodynamics, pharmacokinetics, and delivery of immunomodulatory agents/co-delivery of compounds to prime at the tumor sites for improved therapeutic benefits. This review provides an overview of the design and clinical principles of biomaterials driven nanotechnology and their potential use in personalized nanomedicines, vaccines, localized tumor modulation, and delivery strategies for cancer immunotherapy. In this review, we also summarize the latest highlights and recent advances in combinatorial therapies availed in the treatment of cold and complicated tumors. It also presents key steps and parameters implemented for clinical success. Finally, we analyse, discuss, and provide clinical perspectives on the integrated opportunities of nanotechnology and immunology to achieve synergistic and durable responses in cancer treatment.
Identifiants
pubmed: 33774162
pii: S0939-6411(21)00077-1
doi: 10.1016/j.ejpb.2021.03.010
pmc: PMC8170847
mid: NIHMS1692818
pii:
doi:
Substances chimiques
Cancer Vaccines
0
Drug Carriers
0
Immunologic Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-101Subventions
Organisme : NCI NIH HHS
ID : R01 CA204552
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206069
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA210192
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
Trends Immunol. 2011 Apr;32(4):180-6
pubmed: 21371940
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
Nat Med. 2018 Oct;24(10):1499-1503
pubmed: 30275568
J Am Chem Soc. 2015 Jun 24;137(24):7600-3
pubmed: 26068094
Integr Biol (Camb). 2013 Jan;5(1):231-8
pubmed: 23034721
Nat Commun. 2018 Mar 14;9(1):1074
pubmed: 29540781
Clin Exp Immunol. 2009 Jul;157(1):9-19
pubmed: 19659765
Cell Mol Immunol. 2017 Feb;14(2):223-234
pubmed: 26388236
Ann Oncol. 2012 Sep;23(9):2259-2264
pubmed: 22357252
Sci Transl Med. 2017 Nov 8;9(415):
pubmed: 29118259
Arch Otolaryngol Head Neck Surg. 2005 Dec;131(12):1079-85
pubmed: 16365221
ACS Nano. 2009 Oct 27;3(10):3273-86
pubmed: 19739605
ACS Nano. 2017 Mar 28;11(3):3089-3100
pubmed: 28231431
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Radiology. 2009 Aug;252(2):401-9
pubmed: 19703881
Cell Res. 2018 Apr;28(4):416-432
pubmed: 29472691
ACS Nano. 2018 Feb 27;12(2):1978-1989
pubmed: 29420012
Lancet. 1998 May;351 Suppl 2:SII9-16
pubmed: 9606361
Int J Nanomedicine. 2015 Sep 24;10:5981-92
pubmed: 26451105
Sci Transl Med. 2016 Aug 17;8(352):352ra110
pubmed: 27535621
Nat Commun. 2018 Apr 18;9(1):1532
pubmed: 29670088
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jul;9(4):
pubmed: 28160445
Invest Radiol. 2004 Jan;39(1):56-63
pubmed: 14701989
Nat Nanotechnol. 2007 Dec;2(12):751-60
pubmed: 18654426
Nat Biotechnol. 2015 Jan;33(1):97-101
pubmed: 25503382
Int J Cancer. 2018 Jun 1;142(11):2363-2374
pubmed: 29313975
Trends Mol Med. 2013 Dec;19(12):705-13
pubmed: 24138818
Adv Mater. 2019 Jan;31(3):e1802244
pubmed: 30156333
Chem Soc Rev. 2015 Mar 21;44(6):1302-17
pubmed: 25042637
Nat Med. 2016 Apr;22(4):433-8
pubmed: 26901407
Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1594-1604
pubmed: 28994325
N Engl J Med. 2018 Nov 29;379(22):2108-2121
pubmed: 30345906
Expert Opin Biol Ther. 2018 Oct;18(10):1073-1083
pubmed: 30169979
Crit Care Med. 2017 Feb;45(2):e124-e131
pubmed: 27632680
Sci Transl Med. 2012 May 2;4(132):132ra53
pubmed: 22553251
Nat Methods. 2016 Jul 28;13(8):639-50
pubmed: 27467727
Exp Mol Med. 2018 Dec 13;50(12):1-11
pubmed: 30546008
J Leukoc Biol. 2007 Nov;82(5):1322-31
pubmed: 17711975
Nat Rev Endocrinol. 2017 Apr;13(4):195-207
pubmed: 28106152
N Engl J Med. 2017 Oct 5;377(14):1313-1315
pubmed: 28902570
Photochem Photobiol Sci. 2011 May;10(5):664-9
pubmed: 21258728
Chem Soc Rev. 2019 Jan 2;48(1):351-381
pubmed: 30465669
Clin Cancer Res. 2018 Feb 1;24(3):535-540
pubmed: 29158268
Cardiovasc Res. 2015 Aug 1;107(3):331-9
pubmed: 25994174
Nat Rev Immunol. 2013 May;13(5):349-61
pubmed: 23618831
Int J Cancer. 2005 Apr 20;114(4):613-22
pubmed: 15609328
Adv Drug Deliv Rev. 2011 Mar 18;63(3):136-51
pubmed: 20441782
Nat Commun. 2016 Aug 17;7:12499
pubmed: 27530650
Cancer Cell. 2015 Apr 13;27(4):437-8
pubmed: 25873170
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6639-E6648
pubmed: 27702895
Sci Transl Med. 2013 Aug 7;5(197):197ra103
pubmed: 23926201
Lancet. 2016 Apr 9;387(10027):1540-1550
pubmed: 26712084
Cancer Lett. 2015 Apr 10;359(2):169-77
pubmed: 25633839
J Transl Med. 2005 Feb 21;3(1):9
pubmed: 15723705
J Clin Invest. 2007 May;117(5):1175-83
pubmed: 17476347
J Immunol. 2004 Feb 15;172(4):2126-36
pubmed: 14764678
Oncotarget. 2017 Dec 1;8(70):115748-115753
pubmed: 29383198
Nat Nanotechnol. 2017 Aug;12(8):813-820
pubmed: 28416815
Cell. 2009 Nov 13;139(4):693-706
pubmed: 19878981
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):157-171
pubmed: 26994591
Clin Cancer Res. 2011 Apr 15;17(8):2270-80
pubmed: 21389097
Nat Commun. 2017 Nov 6;8(1):1324
pubmed: 29109393
ACS Nano. 2015 Jun 23;9(6):6401-11
pubmed: 26028363
N Engl J Med. 2018 Nov 22;379(21):2040-2051
pubmed: 30280635
Nano Lett. 2016 Sep 14;16(9):5503-13
pubmed: 27525587
Biomed Opt Express. 2010 Jul 26;1(1):278-284
pubmed: 21258465
Nanoscale Horiz. 2020 Mar 30;5(4):628-653
pubmed: 32226975
Nature. 2017 Jul 13;547(7662):217-221
pubmed: 28678778
Eur J Immunol. 2013 Jun;43(6):1407-12
pubmed: 23568494
Pharm Res. 2011 Feb;28(2):200-14
pubmed: 20821040
J Immunol Res. 2014;2014:149185
pubmed: 24901008
Nat Commun. 2017 Nov 23;8(1):1738
pubmed: 29170503
Clin Cancer Res. 2005 Jul 1;11(13):4905-11
pubmed: 16000589
Nat Rev Immunol. 2002 Sep;2(9):675-87
pubmed: 12209136
Immunity. 2014 Nov 20;41(5):843-52
pubmed: 25517616
Nat Rev Immunol. 2012 Mar 22;12(4):269-81
pubmed: 22437939
Cancer Res. 2001 May 1;61(9):3689-97
pubmed: 11325840
J Clin Oncol. 2015 Jun 10;33(17):1974-82
pubmed: 25605845
Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):728-34
pubmed: 15701862
Br J Cancer. 2007 Nov 19;97(10):1381-7
pubmed: 17971767
J Gene Med. 2012 Jun;14(6):428-39
pubmed: 22262664
PLoS One. 2015 Jul 08;10(7):e0128910
pubmed: 26154425
Nature. 2016 Jun 01;534(7607):396-401
pubmed: 27281205
Pharm Res. 2014 Jun;31(6):1426-37
pubmed: 23568520
Cancer Cell. 2018 Apr 9;33(4):649-663.e4
pubmed: 29576375
Biomaterials. 2015 Aug;61:33-40
pubmed: 25993015
Mol Ther. 2004 May;9(5):757-64
pubmed: 15120337
Nat Rev Immunol. 2009 Mar;9(3):162-74
pubmed: 19197294
Sci Rep. 2017 Jul 5;7(1):4694
pubmed: 28680130
J Control Release. 2014 Oct 28;192:209-18
pubmed: 25068703
Vaccine. 2003 Jun 20;21(21-22):2837-43
pubmed: 12798625
Cancer Immunol Res. 2015 Apr;3(4):356-67
pubmed: 25600436
Biomaterials. 2015 Jan;38:50-60
pubmed: 25457983
Clin Lung Cancer. 2017 Sep;18(5):444-459.e1
pubmed: 28416123
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4041-E4050
pubmed: 29632196
Sci Transl Med. 2018 Feb 21;10(429):
pubmed: 29467299
Nature. 2017 Jul 13;547(7662):222-226
pubmed: 28678784
Neoplasia. 2005 Oct;7(10):904-11
pubmed: 16242073
Clin Cancer Res. 2017 Apr 15;23(8):1929-1936
pubmed: 27756788
Mol Ther Methods Clin Dev. 2016 Dec 31;4:92-101
pubmed: 28344995
Int J Biol Sci. 2011;7(5):651-8
pubmed: 21647333
Lasers Med Sci. 2013 Sep;28(5):1383-92
pubmed: 23455655
Nat Rev Cancer. 2009 Nov;9(11):798-809
pubmed: 19851315
PLoS One. 2016 Jun 24;11(6):e0156626
pubmed: 27341631
Nanotheranostics. 2018 Jun 23;2(4):306-319
pubmed: 29977742
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
RNA Biol. 2012 Nov;9(11):1319-30
pubmed: 23064118
Cancer Immunol Immunother. 2012 Sep;61(9):1387-94
pubmed: 22270715
Adv Mater. 2014 Dec 23;26(48):8154-62
pubmed: 25331930
Mol Pharm. 2018 Sep 4;15(9):4161-4172
pubmed: 30011369
ACS Nano. 2017 Oct 24;11(10):10147-10158
pubmed: 28901740
Nat Nanotechnol. 2016 Mar;11(3):295-303
pubmed: 26689376
J Clin Oncol. 2016 Sep 1;34(25):2969-79
pubmed: 27354481
J Exp Med. 2016 Jun 27;213(7):1133-9
pubmed: 27242164
Carcinogenesis. 2008 May;29(5):964-70
pubmed: 18296681
Sci Adv. 2018 Apr 18;4(4):eaao1736
pubmed: 29675465
Biomaterials. 2016 Jan;75:237-249
pubmed: 26513416
Nat Nanotechnol. 2017 Jul;12(7):692-700
pubmed: 28650441
Orv Hetil. 2006 Jan 22;147(3):121-5
pubmed: 16515031
Nat Commun. 2017 Nov 23;8(1):1747
pubmed: 29170511
J Biomed Nanotechnol. 2016 Apr;12(4):700-9
pubmed: 27301196
J Clin Oncol. 2005 Feb 1;23(4):741-50
pubmed: 15613700
Nat Rev Cancer. 2016 Jan;16(1):56-66
pubmed: 26694936
Annu Rev Immunol. 2013;31:51-72
pubmed: 23157435
Nat Med. 2010 Sep;16(9):1035-41
pubmed: 20711198
Blood. 2018 Jan 4;131(1):49-57
pubmed: 29118009
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819831068
pubmed: 30798772
Adv Drug Deliv Rev. 2017 May 15;114:175-183
pubmed: 28625829
Mol Ther. 2015 Sep;23(9):1541-50
pubmed: 25896248
Magn Reson Med. 1993 Nov;30(5):617-25
pubmed: 8259062
Cancer Res. 2002 Mar 15;62(6):1604-8
pubmed: 11912128
Hum Vaccin Immunother. 2014;10(11):3153-64
pubmed: 25625927
Nature. 2014 Mar 27;507(7493):519-22
pubmed: 24531764
Cell. 2015 Apr 9;161(2):205-14
pubmed: 25860605
J Clin Invest. 2009 Aug;119(8):2231-44
pubmed: 19620771
Nanoscale Res Lett. 2016 Dec;11(1):285
pubmed: 27271853
Nat Mater. 2012 Oct;11(10):895-905
pubmed: 22797827
J Control Release. 2011 May 30;152(1):168-76
pubmed: 21223989
ACS Omega. 2018 Apr 30;3(4):3702-3707
pubmed: 29732445
Trends Immunol. 2017 Aug;38(8):577-593
pubmed: 28610825
Nat Rev Cancer. 2016 Aug 23;16(9):566-81
pubmed: 27550819
Biomaterials. 2014 Jan;35(1):590-600
pubmed: 24125775
Nat Biotechnol. 2007 Oct;25(10):1159-64
pubmed: 17873867
Science. 2013 Dec 20;342(6165):1432-3
pubmed: 24357284
Biomed Microdevices. 2007 Oct;9(5):719-27
pubmed: 17562181
Nat Med. 2004 Sep;10(9):993-8
pubmed: 15334072
Blood. 2018 Jan 4;131(1):39-48
pubmed: 29118006
Nano Lett. 2008 Sep;8(9):2599-606
pubmed: 18386933
J Control Release. 2011 Nov 7;155(3):435-41
pubmed: 21641946
J Clin Invest. 2014 Feb;124(2):687-95
pubmed: 24382348
Eur Radiol. 2008 Oct;18(10):2021-32
pubmed: 18506449
Mol Ther. 2013 Oct;21(10):1919-29
pubmed: 23774794
Clin Cancer Res. 2017 Sep 15;23(18):5349-5357
pubmed: 28634283
Cancer Res. 2014 Mar 15;74(6):1670-81
pubmed: 24480625
Nat Commun. 2015 Aug 12;6:7556
pubmed: 26265369
Nat Commun. 2018 Jan 2;9(1):6
pubmed: 29295974
ACS Nano. 2015 Jul 28;9(7):6918-33
pubmed: 26153897
Vaccines (Basel). 2020 Oct 10;8(4):
pubmed: 33050488
J Pediatr. 1991 Nov;119(5):725-32
pubmed: 1941378
Ann Oncol. 2017 Dec 1;28(suppl_12):xii11-xii17
pubmed: 29253113
Langmuir. 2019 Jun 18;35(24):7805-7815
pubmed: 31090425
Front Pharmacol. 2017 Aug 23;8:561
pubmed: 28878676
Nat Biomed Eng. 2019 Oct;3(10):768-782
pubmed: 31406259
Biomed J. 2019 Oct;42(5):299-306
pubmed: 31783990
Cell. 2017 Feb 9;168(4):724-740
pubmed: 28187291
Int J Pharm. 2013 Mar 10;445(1-2):171-80
pubmed: 23376226
ACS Nano. 2014 Apr 22;8(4):3636-45
pubmed: 24580381
Mol Ther. 2018 Jan 3;26(1):45-55
pubmed: 29258739
Nat Mater. 2018 Jun;17(6):528-534
pubmed: 29507416
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8260-5
pubmed: 26100900
Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8800-5
pubmed: 22847719
Nat Rev Drug Discov. 2016 Sep 29;15(10):663-5
pubmed: 27681782
J Control Release. 2016 Oct 28;240:227-234
pubmed: 26718856
Cancer Res. 2001 Jan 15;61(2):459-61
pubmed: 11212231
Adv Funct Mater. 2013 Aug 1;23(36):4621-4628
pubmed: 24688455
Annu Rev Immunol. 2011;29:235-71
pubmed: 21219185
Crit Rev Oncol Hematol. 2017 Aug;116:116-124
pubmed: 28693793
Front Immunol. 2017 Mar 31;8:304
pubmed: 28408907
Int J Hyperthermia. 2014 Dec;30(8):531-9
pubmed: 25430985
Mol Pharm. 2017 May 1;14(5):1528-1537
pubmed: 28191842
Nat Med. 2013 Apr;19(4):465-72
pubmed: 23455713
Mol Pharm. 2017 May 1;14(5):1760-1770
pubmed: 28296410
Anticancer Res. 2012 Apr;32(4):1119-36
pubmed: 22493341
Sci Rep. 2018 Nov 12;8(1):16673
pubmed: 30420735
Front Biosci (Elite Ed). 2012 Jan 01;4(2):734-45
pubmed: 22201909
Biomed Pharmacother. 2020 Apr;124:109821
pubmed: 31962285
Nat Rev Immunol. 2003 Aug;3(8):609-20
pubmed: 12974476
J Oncol. 2019 Feb 28;2019:4508794
pubmed: 30941175
Nat Mater. 2009 Feb;8(2):151-8
pubmed: 19136947
Nat Rev Drug Discov. 2018 Apr;17(4):261-279
pubmed: 29326426
Nano Lett. 2017 Oct 11;17(10):6366-6375
pubmed: 28858519
Pharm Res. 2010 Sep;27(9):2008-17
pubmed: 20602152
J Clin Oncol. 2007 May 20;25(15):2000-5
pubmed: 17420510
Annu Rev Biomed Eng. 2011 Aug 15;13:507-30
pubmed: 21639780
Pharmacol Ther. 2020 Mar;207:107456
pubmed: 31863820
N Engl J Med. 2017 Dec 28;377(26):2545-2554
pubmed: 29226764
J Immunol Res. 2015;2015:794528
pubmed: 26665011
Adv Drug Deliv Rev. 2017 May 15;114:79-101
pubmed: 28545888
Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):862-70
pubmed: 14967443
J Control Release. 2012 Jun 10;160(2):117-34
pubmed: 22484195
Invest Radiol. 2013 Jun;48(6):492-9
pubmed: 23249649
Biomaterials. 2012 Jun;33(19):4957-64
pubmed: 22484047
Nano Lett. 2016 Apr 13;16(4):2334-40
pubmed: 26999507
Mol Pharm. 2007 Jan-Feb;4(1):73-84
pubmed: 17274665
Vaccine. 2008 Jul 4;26(29-30):3662-72
pubmed: 18538453
Biomaterials. 2008 Sep;29(27):3671-3682
pubmed: 18565578
Biomaterials. 2012 Apr;33(11):3235-42
pubmed: 22296829
Nat Rev Drug Discov. 2017 Jun;16(6):400-423
pubmed: 28154410
J Immunol. 2012 Jul 15;189(2):558-66
pubmed: 22685313
Biomaterials. 2014 Mar;35(8):2477-87
pubmed: 24345735
Nano Lett. 2014;14(4):2181-8
pubmed: 24673373
ACS Nano. 2018 Oct 23;12(10):9830-9841
pubmed: 30253648
N Engl J Med. 2018 Jan 11;378(2):158-168
pubmed: 29320654
Front Oncol. 2015 Feb 03;5:15
pubmed: 25692097
Nat Nanotechnol. 2016 Nov;11(11):986-994
pubmed: 27668795
Cell Immunol. 2010;263(1):79-87
pubmed: 20346445
Int J Cancer. 2009 Sep 1;125(5):1016-26
pubmed: 19405120
Trends Immunol. 2010 Jun;31(6):220-7
pubmed: 20538542
Sci Transl Med. 2015 Sep 2;7(303):303ra139
pubmed: 26333935
PLoS One. 2010 Aug 10;5(8):e11995
pubmed: 20706632
Cancers (Basel). 2011 Oct 13;3(4):3856-93
pubmed: 24213115
J Control Release. 2013 Dec 10;172(2):426-35
pubmed: 23770010
J Control Release. 2011 Sep 25;154(3):249-57
pubmed: 21704093
Nat Rev Immunol. 2009 Aug;9(8):581-93
pubmed: 19498381
PLoS One. 2013 Jul 23;8(7):e69073
pubmed: 23935927
Sci Transl Med. 2017 Jul 19;9(399):
pubmed: 28724573
Proc Staff Meet Mayo Clin. 1957 Sep 4;32(18):478-84
pubmed: 13465828
Cell Death Differ. 2008 Jan;15(1):80-8
pubmed: 17932500
Ann Oncol. 2016 Apr;27(4):559-74
pubmed: 26715621
Nano Rev. 2010;1:
pubmed: 22110864
Science. 2015 Apr 3;348(6230):69-74
pubmed: 25838375
N Engl J Med. 2018 May 31;378(22):2078-2092
pubmed: 29658856
Curr Opin Immunol. 2014 Apr;27:1-7
pubmed: 24413387
Adv Mater. 2016 Oct;28(40):8912-8920
pubmed: 27558441
Sci Transl Med. 2017 May 10;9(389):
pubmed: 28490665
Adv Funct Mater. 2015 Jul 15;25(27):4183-4194
pubmed: 27340392
Clin Cancer Res. 2016 Mar 15;22(6):1459-68
pubmed: 26546617
Ann Transl Med. 2019 Oct;7(20):595
pubmed: 31807576
J Exp Med. 2013 Aug 26;210(9):1695-710
pubmed: 23897981
Curr Opin Immunol. 2016 Apr;39:1-6
pubmed: 26609943
Sci Rep. 2017 Aug 17;7(1):8606
pubmed: 28819209
Best Pract Res Clin Haematol. 2003 Mar;16(1):69-81
pubmed: 12670466
Adv Healthc Mater. 2015 Jun 3;4(8):1180-9
pubmed: 25866054
J Immunother Cancer. 2017 Mar 21;5:22
pubmed: 28344808
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Biologics. 2014 Feb 10;8:27-38
pubmed: 24596453
Biomaterials. 2017 Nov;146:136-145
pubmed: 28918263
AAPS J. 2015 Jan;17(1):184-93
pubmed: 25331103
Radiat Oncol. 2014 Aug 15;9:180
pubmed: 25127546
Nat Mater. 2017 Apr;16(4):489-496
pubmed: 28024156
Nat Nanotechnol. 2011 Sep 11;6(10):675-82
pubmed: 21909083
Theranostics. 2018 Jan 1;8(3):860-873
pubmed: 29344312
Adv Mater. 2018 Feb;30(8):
pubmed: 29318677
Theranostics. 2017 Jul 23;7(13):3276-3292
pubmed: 28900509
N Engl J Med. 2010 Jul 29;363(5):411-22
pubmed: 20818862
PLoS One. 2009;4(3):e4942
pubmed: 19319200
Circulation. 2010 Oct 26;122(17):1707-15
pubmed: 20937980
Clin Cancer Res. 2008 Jan 1;14(1):169-77
pubmed: 18172268
Nat Mater. 2014 Feb;13(2):125-38
pubmed: 24452356
Oncol Res. 2014;21(5):227-35
pubmed: 24854099
Nat Rev Immunol. 2015 Jun;15(6):335-49
pubmed: 25976513
Chem Rev. 2017 Feb 8;117(3):901-986
pubmed: 28045253
ACS Nano. 2018 Dec 26;12(12):12015-12029
pubmed: 30508377
Int J Cancer. 2013 Feb 15;132(4):967-77
pubmed: 22870862
Nat Commun. 2016 Oct 21;7:13193
pubmed: 27767031
Immunotherapy. 2017 Mar;9(4):347-360
pubmed: 28303764
Blood. 2013 Aug 8;122(6):863-71
pubmed: 23770775
J Clin Oncol. 2017 Mar;35(7):709-717
pubmed: 27646942
J Clin Oncol. 2010 Oct 1;28(28):4324-32
pubmed: 20697067
Biomaterials. 2015 Feb;40:88-97
pubmed: 25465442
Biomaterials. 2012 Jun;33(19):4872-81
pubmed: 22483011
ACS Nano. 2014 Jun 24;8(6):5670-81
pubmed: 24801008
PLoS One. 2013 May 01;8(5):e61825
pubmed: 23650505
Nat Biotechnol. 2015 Jan;33(1):64-72
pubmed: 25485616
Nat Biomed Eng. 2018 Aug;2(8):578-588
pubmed: 31015631
Int J Nanomedicine. 2016 Jun 01;11:2481-90
pubmed: 27330291
Nano Lett. 2017 Dec 13;17(12):7387-7393
pubmed: 29144754
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Clin Cancer Res. 2015 Aug 15;21(16):3771-82
pubmed: 25967142
Biomaterials. 2012 Aug;33(22):5584-92
pubmed: 22575830
Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1128-35
pubmed: 21093169
J Am Chem Soc. 2012 Jul 18;134(28):11358-61
pubmed: 22734608
Clin Exp Immunol. 2016 Nov;186(2):249-265
pubmed: 27227483
Mol Pharm. 2010 Oct 4;7(5):1643-54
pubmed: 20804176
Nano Today. 2009 Oct 1;4(5):399-413
pubmed: 20161038
Biomaterials. 2014 Aug;35(24):6646-56
pubmed: 24818880
Mol Immunol. 2015 Mar;64(1):36-45
pubmed: 25467796
Adv Drug Deliv Rev. 2017 Jun 1;115:57-81
pubmed: 28412324
Lancet. 2019 May 4;393(10183):1819-1830
pubmed: 30955977
Microbes Infect. 2007 Nov-Dec;9(14-15):1614-22
pubmed: 17905628
Nat Rev Cancer. 2016 Feb;16(2):121-6
pubmed: 26822578
Nanomedicine. 2014 Aug;10(6):1273-1285
pubmed: 24566274
J Immunol. 2001 Jun 15;166(12):7309-18
pubmed: 11390481
Biomaterials. 2015 Nov;68:54-66
pubmed: 26264646
Nanomedicine (Lond). 2014 Jul;9(14):2187-202
pubmed: 25405796
Nat Rev Immunol. 2018 Mar;18(3):212-219
pubmed: 28853444
J Am Chem Soc. 2016 Dec 28;138(51):16686-16695
pubmed: 27976881
Biomaterials. 2014 Sep;35(27):7992-8001
pubmed: 24954733
Cancer Res. 2003 Oct 15;63(20):6838-46
pubmed: 14583481
Nat Mater. 2005 Jun;4(6):435-46
pubmed: 15928695
ACS Nano. 2017 May 23;11(5):4463-4474
pubmed: 28362496
Nat Rev Drug Discov. 2019 Mar;18(3):175-196
pubmed: 30622344
Biomater Sci. 2019 Feb 26;7(3):715-732
pubmed: 30762040