Sex neurosteroids: Hormones made by the brain for the brain.
Animals
Cell Differentiation
Dihydrotestosterone
/ metabolism
Estradiol
/ metabolism
Estrous Cycle
Female
Gonadotropin-Releasing Hormone
/ metabolism
Hippocampus
/ cytology
Humans
Hypothalamus
/ cytology
Male
Neuronal Plasticity
Neurons
/ metabolism
Neurosteroids
/ metabolism
Sex Factors
Synaptic Transmission
Hippocampus
LTP
Sex steroids
Sex-specificity
Synaptic plasticity
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
14 05 2021
14 05 2021
Historique:
received:
08
12
2020
revised:
09
03
2021
accepted:
22
03
2021
pubmed:
30
3
2021
medline:
23
11
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
In general, hippocampal neurons are capable of synthesizing sex steroids de novo from cholesterol, since the brain is equipped with all the enzymes required for the synthesis of estradiol and testosterone, the end products of sex steroidogenesis. Regarding estradiol, its synthesis in hippocampal neurons is homeostatically controlled by Ca
Identifiants
pubmed: 33775739
pii: S0304-3940(21)00227-5
doi: 10.1016/j.neulet.2021.135849
pii:
doi:
Substances chimiques
Neurosteroids
0
Dihydrotestosterone
08J2K08A3Y
Gonadotropin-Releasing Hormone
33515-09-2
Estradiol
4TI98Z838E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135849Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.