Validating a model for medication-related dental outcomes in older people.
aged
dementia
dental care
polypharmacy
tooth loss
xerostomia
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
07
03
2021
received:
14
01
2021
accepted:
24
03
2021
pubmed:
30
3
2021
medline:
12
8
2022
entrez:
29
3
2021
Statut:
ppublish
Résumé
To externally validate a model for medication-related dental outcomes in (a) a general older population with dementia and (b) a matched population without dementia. This validation study used population-based data from seven Swedish national registers (2008-2017). Individuals aged 60+ with dementia were matched to those without dementia on age, gender, and county of residence at the date of diagnosis (index date). The exposure was continuous use of xerogenic medications during the 3-year period before index date. The primary outcome was the number of tooth extraction and restorative procedures within 3 years after index date. A total of 334,220 individuals were included in the final sample. In the dementia cohort, the use of urological drugs (incidence rate ratio [IRR] 1.08, 95% CI 1.03-1.13), respiratory medicines (IRR 1.10, 95% CI 1.04-1.17), and proton-pump inhibitors (IRR 1.09, 95% CI 1.05-1.13) was associated with the primary outcome. In the non-dementia cohort, respiratory medicines (IRR 1.03, CI 1.00-1.05), proton-pump inhibitors (IRR 1.06, CI 1.04-1.08), opioids (IRR 1.05, CI 1.03-1.07), and antidepressants (IRR 1.06, CI 1.04-1.08) were associated with the primary outcome. Although there were differences in prescription patterns, the model performed similarly in both those with and without dementia.
Substances chimiques
Proton Pump Inhibitors
0
Types de publication
Journal Article
Langues
eng
Pagination
1697-1704Subventions
Organisme : Stockholm County Council
ID : OF11204423
Organisme : Swedish Association of Local Authorities and Regions
Organisme : NHMRC-ARC Dementia Research Development Fellowship
ID : APP1107381
Informations de copyright
wileyonlinelibrary.com/journal/odi.
Références
Brennan, L. J., & Strauss, J. (2014). Cognitive impairment in older adults and oral health considerations: Treatment and management. Dental Clinics of North America, 58(4), 815-828. https://doi.org/10.1016/j.cden.2014.07.001
Carvalho, T. S., Colon, P., Ganss, C., Huysmans, M. C., Lussi, A., Schlueter, N., Schmalz, G., Shellis, R. P., Tveit, A. B., & Wiegand, A. (2016). Consensus report of the European Federation of Conservative Dentistry: Erosive tooth wear - Diagnosis and management. Swiss Dental Journal, 126(4), 342-346.
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. Journal of Chronic Diseases, 40(5), 373-383. https://doi.org/10.1016/0021-9681(87)90171-8
de Campaigno, E. P., Kebir, I., Montastruc, J.-L., Rueter, M., Maret, D., Lapeyre-Mestre, M., Sallerin, B., & Despas, F. (2017). Drug-induced dental caries: A Disproportionality analysis using data from VigiBase. Drug Safety, 40(12), 1249-1258. https://doi.org/10.1007/s40264-017-0575-5
Delwel, S., Binnekade, T. T., Perez, R., Hertogh, C., Scherder, E. J. A., & Lobbezoo, F. (2018). Oral hygiene and oral health in older people with dementia: A comprehensive review with focus on oral soft tissues. Clinical Oral Investigations, 22(1), 93-108. https://doi.org/10.1007/s00784-017-2264-2
Dmochowski, R. R., Thai, S., Iglay, K., Enemchukwu, E., Tee, S., Varano, S., Girman, C., Radican, L., Mudd, P. N., & Poole, C. (2021). Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis. Neurourology and Urodynamics, 40(1), 28-37. https://doi.org/10.1002/nau.24536
Domenichiello, A. F., & Ramsden, C. E. (2019). The silent epidemic of chronic pain in older adults. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93, 284-290. https://doi.org/10.1016/j.pnpbp.2019.04.006
Fereshtehnejad, S. M., Garcia-Ptacek, S., Religa, D., Holmer, J., Buhlin, K., Eriksdotter, M., & Sandborgh-Englund, G. (2018). Dental care utilization in patients with different types of dementia: A longitudinal nationwide study of 58,037 individuals. Alzheimer's & Dementia: the Journal of the Alzheimer's Association, 14(1), 10-19. https://doi.org/10.1016/j.jalz.2017.05.004
Foley, N. C., Affoo, R. H., Siqueira, W. L., & Martin, R. E. (2017). A systematic review examining the oral health status of persons with dementia. JDR Clinical & Translational Research, 2(4), 330-342. https://doi.org/10.1177/2380084417714789
Griffioen, C., Willems, E. G., Husebo, B. S., & Achterberg, W. P. (2017). Prevalence of the use of opioids for treatment of pain in persons with a cognitive impairment compared with cognitively intact persons: A systematic review. Current Alzheimer Research, 14(5), 512-522. https://doi.org/10.2174/1567205013666160629080735
Lexomboon, D., Gavriilidou, N. N., Höijer, J., Skott, P., Religa, D., Eriksdotter, M., & Sandborgh-Englund, G. (2021). Discontinued dental care attendance among people with dementia: A register-based longitudinal study. Gerodontology. 38(1), 57-65. https://doi.org/10.1111/ger.12498
Lexomboon, D., Tan, E. C. K., Höijer, J., Garcia-Ptacek, S., Eriksdotter, M., Religa, D., Fastbom, J., Johnell, K., & Sandborgh-Englund, G. (2018). The effect of xerostomic medication on oral health in persons with dementia. Journal of the American Medical Directors Association, 19(12), 1080-1085.e1082. https://doi.org/10.1016/j.jamda.2018.05.014
Ljung, R., Lundgren, F., Appelquist, M., & Cederlund, A. (2019). The Swedish dental health register - Validation study of remaining and intact teeth. BMC Oral Health, 19(1), 116. https://doi.org/10.1186/s12903-019-0804-7
Ludvigsson, J. F., Otterblad-Olausson, P., Pettersson, B. U., & Ekbom, A. (2009). The Swedish personal identity number: Possibilities and pitfalls in healthcare and medical research. European Journal of Epidemiology, 24(11), 659-667. https://doi.org/10.1007/s10654-009-9350-y
Ludvigsson, J. F., Svedberg, P., Olén, O., Bruze, G., & Neovius, M. (2019). The longitudinal integrated database for health insurance and labour market studies (LISA) and its use in medical research. European Journal of Epidemiology, 34, 423-437. https://doi.org/10.1007/s10654-019-00511-8
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J.-C., Saunders, L. D., Beck, C. A., Feasby, T. E., & Ghali, W. A. (2005). Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Medical Care, 43(11), 1130-1139. https://doi.org/10.1097/01.mlr.0000182534.19832.83
Religa, D., Fereshtehnejad, S.-M., Cermakova, P., Edlund, A.-K., Garcia-Ptacek, S., Granqvist, N., Hallbäck, A., Kåwe, K., Farahmand, B., Kilander, L., Mattsson, U.-B., Nägga, K., Nordström, P., Wijk, H., Wimo, A., Winblad, B., & Eriksdotter, M. (2015). SveDem, the Swedish Dementia Registry - A tool for improving the quality of diagnostics, treatment and care of dementia patients in clinical practice. PLoS One, 10(2), e0116538. https://doi.org/10.1371/journal.pone.0116538
Scully, C. (2003). Drug effects on salivary glands: Dry mouth. Oral Diseases, 9(4), 165-176. https://doi.org/10.1034/j.1601-0825.2003.03967.x
Statistics Sweden (2020). The Total Population Register (RTB). Statistics Sweden. Retrieved from https://www.scb.se/vara-tjanster/bestalla-mikrodata/vilka-mikrodata-finns/individregister/registret-over-totalbefolkningen-rtb/
Tan, E. C. K., Lexomboon, D., Häbel, H., Fastbom, J., Eriksdotter, M., Johnell, K., & Sandborgh-Englund, G. (2020). Xerogenic medications as a predictor for dental health intervention in people with dementia. Journal of Alzheimer's Disease, 75(4), 1263-1271. https://doi.org/10.3233/jad-200148
Tan, E. C. K., Lexomboon, D., Sandborgh-Englund, G., Haasum, Y., & Johnell, K. (2018). Medications that cause dry mouth as an adverse effect in older people: A systematic review and metaanalysis. Journal of the American Geriatrics Society, 66(1), 76-84. https://doi.org/10.1111/jgs.15151
Teare, J. P., Spedding, C., Whitehead, M. W., Greenfield, S. M., Challacombe, S. J., & Thompson, R. P. (1995). Omeprazole and dry mouth. Scandinavian Journal of Gastroenterology, 30(3), 216-218. https://doi.org/10.3109/00365529509093266
The National Board of Health and Welfare (2020). The Swedish Prescribed Drug Register. The National Board of Health and Welfare. Retrieved from https://www.socialstyrelsen.se/en/statistics-and-data/registers/register-information/the-swedish-prescribed-drug-register/
The National Board of Health and Welfare (2020a). The care and social services for the elderly and for persons with impairments register (SOL). The National Board of Health and Welfare. Retrieved from https://www.socialstyrelsen.se/statistik-och-data/register/alla-register/aldre-och-personer-med-funktionsnedsattning/
The National Board of Health and Welfare (2020b). The Dental Health Register. The National Board of Health and Welfare. Retrieved from https://www.socialstyrelsen.se/statistik-och-data/register/alla-register/tandhalsoregistret/
The National Board of Health and Welfare (2020c). The National Quality Registry for Dementia (SveDem). The National Board of Health and Welfare. Retrieved from http://kvalitetsregister.se/englishpages/findaregistry/registerarkivenglish/nationalqualityregistryfordementiasvedem.2159.html
The National Board of Health and Welfare (2020d). The Swedish National Patient Register. The National Board of Health and Welfare. Retrieved from https://www.socialstyrelsen.se/en/statistics-and-data/registers/register-information/the-national-patient-register/
Volicer, L., Frijters, D. H. M., & van der Steen, J. T. (2011). Underdiagnosis and undertreatment of depression in nursing home residents. European Geriatric Medicine, 2(6), 332-337. https://doi.org/10.1016/j.eurger.2011.08.001
Wastesson, J. W., Morin, L., Tan, E. C. K., & Johnell, K. (2018). An update on the clinical consequences of polypharmacy in older adults: A narrative review. Expert Opinion on Drug Safety, 17(12), 1185-1196. https://doi.org/10.1080/14740338.2018.1546841
Wettermark, B., Hammar, N., MichaelFored, C., Leimanis, A., Otterblad Olausson, P., Bergman, U., Persson, I., Sundström, A., Westerholm, B., & Rosén, M. (2007). The new Swedish Prescribed Drug Register-opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiology and Drug Safety, 16(7), 726-735. https://doi.org/10.1002/pds.1294
Wolff, A., Joshi, R. K., Ekström, J., Aframian, D., Pedersen, A. M. L., Proctor, G., Narayana, N., Villa, A., Sia, Y. W., Aliko, A., McGowan, R., Kerr, A. R., Jensen, S. B., Vissink, A., & Dawes, C. (2017). A guide to medications inducing salivary gland dysfunction, xerostomia, and subjective sialorrhea: A systematic review sponsored by the World Workshop on Oral Medicine VI. Drugs in R&D, 17(1), 1-28. https://doi.org/10.1007/s40268-016-0153-9
Yanai-Inamura, H., Ohtake, A., Noguchi, Y., Hatanaka, T., Suzuki, M., Ueshima, K., Sato, S., & Sasamata, M. (2012). Effects of α1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats. European Journal of Pharmacology, 679(1-3), 127-131. https://doi.org/10.1016/j.ejphar.2012.01.019